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Sodium thiosulfate is a classical antidote to cyanide poisoning, [10] For this purpose it is used after the medication sodium nitrite and typically only recommended for severe cases. [4] [6] It is given by injection into a vein. [4] In this use, sodium nitrite creates methemoglobinemia which removes cyanide from mitochondria. [6]
Sodium thiosulfate is used in the treatment of cyanide poisoning. [3] It is on the World Health Organization's List of Essential Medicines. [4] [5] Other uses include topical treatment of ringworm and tinea versicolor, [3] [6] and treating some side effects of hemodialysis [7] and chemotherapy.
Thiosulfate: The evidence for sodium thiosulfate's use is based on animal studies and case reports: the small quantities of cyanide present in dietary sources and in cigarette smoke are normally metabolized to relatively harmless thiocyanate by the mitochondrial enzyme rhodanese (thiosulfate cyanide sulfurtransferase), which uses thiosulfate as ...
Amobarbital, one of the chemical compounds that can be used as a truth serum. Sedatives or hypnotics that alter higher cognitive function include ethanol, scopolamine, 3-quinuclidinyl benzilate, potent short or intermediate acting hypnotic benzodiazepines such as midazolam, flunitrazepam, and various short and ultra-short acting barbiturates, including sodium thiopental (commonly known by the ...
Thiosulfate (IUPAC-recommended spelling; sometimes thiosulphate in British English) is an oxyanion of sulfur with the chemical formula S 2 O 2− 3.Thiosulfate also refers to the compounds containing this anion, which are the salts of thiosulfuric acid, such as sodium thiosulfate Na 2 S 2 O 3 and ammonium thiosulfate (NH 4) 2 S 2 O 3.
Sodium nitrite/sodium thiosulfate, sold under the brand name Nithiodote, is a fixed-dose combination medication used as an antidote for cyanide poisoning. [1] It contains sodium thiosulfate and sodium nitrite. [1] It is given by intravenous infusion into a vein. [1] It was approved for medical use in the United States in January 2011. [2]
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