Search results
Results from the WOW.Com Content Network
Transferrin glycoproteins bind iron tightly, but reversibly. Although iron bound to transferrin is less than 0.1% (4 mg) of total body iron, it forms the most vital iron pool with the highest rate of turnover (25 mg/24 h). Transferrin has a molecular weight of around 80 kDa and contains two specific high-affinity Fe(III) binding sites.
Large amounts of free iron in the circulation will cause damage to critical cells in the liver, the heart and other metabolically active organs. Iron toxicity results when the amount of circulating iron exceeds the amount of transferrin available to bind it, but the body is able to vigorously regulate its iron uptake.
free 8-24 × 10 −12: total 4-12 × 10 −8: Thyroxine-binding prealbumin: 2.8-3.5 × 10 −4: Thyroxine-binding globulin: 1.0-3.4 × 10 −7: Tin: 0-4 × 10 −7: 0-1 × 10 −7: alpha-Tocopherol (Vitamin E) 5-20 × 10 −6: Transcortin: male 1.5-2 × 10 −5: female 1.6-2.5 × 10 −5: Transferrin: newborn 1.3-2.75 × 10 −3: adult 2.2-4 × ...
Serum iron is a medical laboratory test that measures the amount of circulating iron that is bound to transferrin and freely circulate in the blood. Clinicians order this laboratory test when they are concerned about iron deficiency, which can cause anemia and other problems. 65% of the iron in the body is bound up in hemoglobin molecules in red blood cells.
Total iron-binding capacity (TIBC) or sometimes transferrin iron-binding capacity is a medical laboratory test that measures the blood's capacity to bind iron with transferrin. [1] Transferrin can bind two atoms of ferric iron (Fe 3+ ) with high affinity.
Beta-2 transferrin is a carbohydrate-free isoform of transferrin, which is almost exclusively found in the cerebrospinal fluid. It is not found in blood , mucus or tears , thus making it a specific marker of cerebrospinal fluid, applied as an assay in cases where cerebrospinal fluid leakage is suspected.
A glycoprotein is a compound containing carbohydrate (or glycan) covalently linked to protein. The carbohydrate may be in the form of a monosaccharide, disaccharide(s), oligosaccharide(s), polysaccharide(s), or their derivatives (e.g. sulfo- or phospho-substituted).
PubChem is a database of chemical molecules and their activities against biological assays.The system is maintained by the National Center for Biotechnology Information (NCBI), a component of the National Library of Medicine, which is part of the United States National Institutes of Health (NIH).