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These reactive chemical species can reach DNA by diffusion and the bimolecular reaction damages the DNA (oxidative stress). Unlike direct DNA damage which causes sunburn, indirect DNA damage does not result in any warning signal or pain in the human body. The bimolecular reactions that cause the indirect DNA damage are illustrated in the figure:
The band started in high school as the Domingos. Original group members included Nick Marinelli, Ernie Dernai, Linda Allen and Bob Kerr. [2] By 1965, The Domingos signed a recording contract for the Detroit-based Golden World label. John Rhys, a sound engineer, suggested a name change and the Shades of Blue was the result. [3]
An arsenal of DNA repair mechanisms exists to repair various forms of damaged DNA and minimize genomic instability. Most DNA repair mechanisms require an intact DNA strand as template to fix the damaged strand. DNA damage prevents the normal enzymatic synthesis of DNA by the replication fork.
Radiolysis of intracellular water by ionizing radiation creates peroxides, which are relatively stable precursors to hydroxyl radicals. 60%–70% of cellular DNA damage is caused by hydroxyl radicals, [3] yet hydroxyl radicals are so reactive that they can only diffuse one or two molecular diameters before reacting with cellular components.
A nearly 25-year-old rape and murder cold case has been solved due to DNA forensics and genetics, the Broward County Sheriff’s Office said at a news conference Tuesday.
A pair of men already serving life behind bars have been charged in two Tampa Bay-area cold case murders thanks to DNA evidence that previously helped exonerate a death row inmate.
Nucleotide excision repair (NER) is a particularly important excision mechanism that removes DNA damage induced by ultraviolet light (UV). UV DNA damage results in bulky DNA adducts — these adducts are mostly thymine dimers and 6,4-photoproducts. Recognition of the damage leads to removal of a short single-stranded DNA segment that contains ...
A Florida woman’s brutal killing nearly 25 years ago has been solved after authorities arrested the suspect this week, according to the Sanford Police Department. A Florida woman was killed 24 ...