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They have been designed to be similar to THC, [9] the natural cannabinoid with the strongest binding affinity to the CB 1 receptor, which is linked to the psychoactive effects or "high" of marijuana. [10] These synthetic analogs often have greater binding affinity and greater potency to the CB 1 receptors.
Based on the results of 3 high quality trials and 5 of lower quality, oral cannabis extract was rated as effective, and THC as probably effective, for improving people's subjective experience of spasticity. Oral cannabis extract and THC both were rated as possibly effective for improving objective measures of spasticity. [74] [75]
CBN was the first cannabis compound to be isolated from cannabis extract in the late 1800s. Its structure and chemical synthesis were achieved by 1940 [ 34 ] , followed by some of the first pre-clinical research studies to determine the effects of individual cannabis-derived compounds in vivo . [ 35 ]
Research has shown that Humulus lupulus (the plant that makes hops) and Cannabis sativa (also called hemp and marijuana) are closely related, [1] [a] and it may be possible to create novel cultivars of hops that express valuable chemicals similar to commercial hemp.
Similar to THC, THCV has 7 possible double bond isomers and 30 stereoisomers (see: Tetrahydrocannabinol#Isomerism). The alternative isomer Δ 8-THCV is known as a synthetic compound with a code number of O-4395, [5] but it is not known to have been isolated from Cannabis plant material. O-4395 (Δ 8-THCV), 31262-38-1
New research published in The Lancet details an association between high cannabis potency — or concentration of tetrahydrocannabinol (THC) — and an increased risk of psychosis and cannabis use ...
Hexahydrocannabinol (HHC) is a hydrogenated derivative of tetrahydrocannabinol (THC). It is a naturally occurring phytocannabinoid that has rarely been identified as a trace component in Cannabis sativa, [1] [2] but can also be produced synthetically by firstly acid cyclization of cannabidiol and then hydrogenation of tetrahydrocannabinol.
Marijuana remains illegal in Wisconsin after 10 years of debate, but products that pack the same punch as marijuana are being openly sold, thanks to a loophole in federal law.