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tert-Butyloxycarbonyl protecting group. The tert-butyloxycarbonyl protecting group or tert-butoxycarbonyl protecting group [1] (BOC group) is an acid-labile protecting group used in organic synthesis. The BOC group can be added to amines under aqueous conditions using di-tert-butyl dicarbonate in the presence of a base such as sodium hydroxide:
Layers of the skin. Drugs administered through topical application can act locally or systemically. [1] [6] However, the drug molecules must first be retained in and penetrate the surface layer of the skin. [6] Absorption of the drug through the skin surface is a passive process of diffusion.
There are many other terms for creams designed to protect skin from harmful substances, including skin protective creams, pre-work creams, antisolvent gels, protective ointments, [2] and shielding lotions. [3] Three classes of barrier creams are used: water repellent creams, water-soluble creams, and creams designed for special applications. [4]
Tert-Butylamine; Butylated hydroxyanisole; Butylated hydroxytoluene; 4-tert-Butylbenzaldehyde; N-tert-Butylbenzenesulfinimidoyl chloride; Para-tert-Butylbenzoic acid; 4-tert-Butylcatechol; Tert-Butyldiphenylsilyl; Tert-Butylhydroquinone; Tert-Butyllithium; Tert-Butyloxycarbonyl protecting group; Tert-Butylphosphaacetylene; Tert-Butylthiol; N-t ...
Topical cream formulation is an emulsion semisolid dosage form that is used for skin external application. Most of the topical cream formulations contain more than 20 per cent of water and volatiles and/or less than 50 per cent of hydrocarbons , waxes , or polyethylene glycols as the vehicle for external skin application. [ 1 ]
The tert-butyloxycarbonyl group is marked blue. Amines have a special importance in peptide synthesis, but are a quite potent nucleophile and also relatively strong bases. These characteristics imply that new protecting groups for amines are always under development. [47] Amine groups are primarily protected through acylation, typically as a ...
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