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They are one of the most widespread motifs found in protein-protein interactions. To aid protein study, several tools have been developed to predict coiled-coils in protein structures. [3] Many coiled coil-type proteins are involved in important biological functions, such as the regulation of gene expression — e.g., transcription factors.
Coiled-coil research began in 1953 when Dr. Francis Crick first reported on the theory behind the packing formation of α-helices in fibrous proteins at the time, which he proposed to consist of alpha helices composed of heptad repeats, or seven-residue repeats (a-b-c-d-e-f-g), whereby 2 or more alpha helices twist around each other similar to the strands of a rope. [2]
The protein has 17 predicted alpha helices sites, a characteristic of coiled-coil proteins, and 1 predicted beta-pleated sheet. The following image shows the predicted regions of alpha helices and beta pleated sheets by two programs STRAP [ 9 ] and Quickphyre: [ 10 ] Note: the consensus secondary structures are shown.
WD Repeat and Coiled-coiled containing protein (WDCP) is a protein which in humans is encoded by the WDCP gene. The function of the protein is not completely understood, but WDCP has been identified in a fusion protein with anaplastic lymphoma kinase found in colorectal cancer . [ 5 ]
Coiled-Coil Domain Containing protein 82 (CCDC82) is a protein that in humans, is encoded for by the gene of the same name, CCDC82. The CCDC82 gene is expressed in nearly all of human tissues at somewhat low rates. As of today, there are no patents involving CCDC82 and the function remains unknown.
67179 Ensembl ENSG00000147419 ENSMUSG00000022035 UniProt Q86WR0 Q78PG9 RefSeq (mRNA) NM_001304529 NM_001304530 NM_001304532 NM_018246 NM_145944 RefSeq (protein) NP_001291458 NP_001291459 NP_001291461 NP_060716 NP_666056 Location (UCSC) Chr 8: 27.73 – 27.77 Mb Chr 14: 66.07 – 66.1 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The Coiled-Coil Domain Containing Protein – 25 ...
This protein for this gene is also known as coiled coil domain containing 144A (CCDC144A) protein. It consists of 641 amino acids. [9] This protein weighs 75.8 kDa and has an isoelectric point of 6.357. [10] This protein localizes near the nucleus, [11] and is a soluble protein with a hydrophobicity of -1.021842. [12]
Coiled coil domain containing protein 120 (CCDC120), also known as JM11 protein, is a protein that, in humans, is encoded by the CCDC120 gene. [5] The function of CCDC120 has not been formally identified but structural components, conservation, and interactions can be identified computationally.
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