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Cellular senescence is a phenomenon characterized by the cessation of cell division. [ 1 ][ 2 ][ 3 ] In their experiments during the early 1960s, Leonard Hayflick and Paul Moorhead found that normal human fetal fibroblasts in culture reach a maximum of approximately 50 cell population doublings before becoming senescent. [ 4 ][ 5 ][ 6 ] This ...
Senescence (/ sɪˈnɛsəns /) or biological aging is the gradual deterioration of functional characteristics in living organisms. Whole organism senescence involves an increase in death rates or a decrease in fecundity with increasing age, at least in the later part of an organism's life cycle. [ 1 ][ 2 ] However, the resulting effects of ...
Genetics of aging. Many life span influencing genes affect the rate of DNA damage or DNA repair. Genetics of aging is generally concerned with life extension associated with genetic alterations, rather than with accelerated aging diseases leading to reduction in lifespan. The first mutation found to increase longevity in an animal was the age-1 ...
By substantially reducing carbohydrate intake, the ketogenic diet decreases insulin-related activity and encourages autophagy, potentially aiding cellular detoxification and promoting longevity ...
Senescent cells have a low pH due to their high lysosomal content and leaking lysosomal membranes. This low pH forms the basis of senescence-associated beta-galactosidase (SA-β-gal) staining of senescent cells. To help neutralize their low pH, senescent cells produce high levels of GLS1; inhibiting the activity of this enzyme exposes senescent ...
Many health experts debate over whether or not intermittent fasting is healthy. Researchers from the University of Illinois Chicago have debunked four common myths about intermittent fasting to ...
A senolytic (from the words senescence and -lytic, "destroying") is among a class of small molecules under basic research to determine if they can selectively induce death of senescent cells and improve health in humans. [100] A goal of this research is to discover or develop agents to delay, prevent, alleviate, or reverse age-related diseases.
Fasting is abstention from eating, and sometimes drinking. However, from a purely physiological context, "fasting" may refer to the metabolic status of a person who has not eaten overnight (before "breakfast"), or to the metabolic state achieved after complete digestion and absorption of a meal. [1] Metabolic changes in the fasting state begin ...