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In transfusion medicine, transfusion-associated circulatory overload (aka TACO) is a transfusion reaction (an adverse effect of blood transfusion) resulting in signs or symptoms of excess fluid in the circulatory system (hypervolemia) within 12 hours after transfusion. [2]
Aware of the rising demand for plasma for transfusion, Dr. Josep Antoni Grífols-Lucas conducted the first systematic study of the application of plasmapheresis in a series of plasma donors. Performed in 1951, this was the most exhaustive study to date of the medium-term effects on the human body, and involved more than 320 plasmapheresis ...
Side effects include nausea and itchiness. [3] Rarely there may be allergic reactions, blood clots, or infections. [1] [3] It is unclear if use during pregnancy or breastfeeding is safe for the baby. [2] Greater care should be taken in people with protein S deficiency, IgA deficiency, or heart failure. [2]
[15] [16] The benefits of single unit transfusion include reduced exposure to blood products. Each unit transfused increases the associated risks of transfusion such as infection, transfusion associated circulatory overload and other side effects. [17] [18] Transfusion of a single unit also encourages less wastage of red blood cells. [19]
Transfusion-related immune modulation has been thought to be the underlying mechanism. [6] Washing red cells has been thought to be one way of potentially decreasing the risk of theses transfusion-related side-effects. [6] However, in neonates, there is insufficient evidence to say whether washing red cells has any effect. [6]
An exchange transfusion is a blood transfusion in which the patient's blood or components of it are exchanged with (replaced by) other blood or blood products. [1] The patient's blood is removed and replaced by donated blood or blood components. This exchange transfusion can be performed manually or using a machine . [2]
Some severe side effects with long-term consequences may include pancreatitis, acute kidney injury, gallstones, gallbladder disease, diabetic retinopathy, and an increased heart rate. Semaglutide ...
Transfusion hemosiderosis can cause permanent damage to tissues that may lead to death. [2] Tissue damage can remain even after chelation therapy. [2] Outcomes are usually worse in patients who require blood transfusions compared to those who can have alternative therapies. [2] Cardiomyopathy and cardiac arrhythmia are often a cause of death. [1]