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Post-treatment monitoring Osteopontin (OPN) is a promising tool for monitoring praziquantel efficacy and post-treatment fibrosis regression as (OPN) expression is modulated by S. mansoni egg antigens and its levels correlate with severity of schistosomiasis fibrosis and portal hypertension in mice and humans. Praziquantel pharmacotherapy ...
The adult lives in the blood vessels (mesenteric veins) near the human intestine. It causes intestinal schistosomiasis (similar to S. japonicum, S. mekongi, S. guineensis, and S. intercalatum). Clinical symptoms are caused by the eggs. As the leading cause of schistosomiasis in the world, it is the most prevalent parasite in humans.
The adult worms can cause inflammation, damage to the organs and various symptoms. The symptoms of schistosomiasis may vary depending on the extent of the infection, the species of the parasite and the host's immune response. The acute phase of the infection may present with fever, rash, abdominal pain and diarrhea.
Schistosoma is a genus of trematodes, commonly known as blood flukes.They are parasitic flatworms responsible for a highly significant group of infections in humans termed schistosomiasis, which is considered by the World Health Organization to be the second-most socioeconomically devastating parasitic disease (after malaria), with hundreds of millions infected worldwide.
Symptoms of all forms of schistosomiasis are caused by the immune system's reaction to the eggs, rather than the adult worms themselves. [5] A few hours to days after cercariae invade the skin, some people experience pruritus and raised papules at the site of penetration. This is called cercarial dermatitis, also known as swimmer's itch.
It is found in Africa and the Middle East. It is the major agent of schistosomiasis, the most prevalent parasitic infection in humans. [1] It is the only blood fluke that infects the urinary tract, causing urinary schistosomiasis, and is the leading cause of bladder cancer (only next to tobacco smoking). [2] [3] The diseases are caused by the eggs.
Current treatments can relieve some of the symptoms, and new disease-modifying treatments are not widely available. ... show characteristic signs of Alzheimer’s such as beta-amyloid plaques ...
The signs and symptoms of helminthiasis depend on a number of factors including: the site of the infestation within the body; the type of worm involved; the number of worms and their volume; the type of damage the infesting worms cause; and, the immunological response of the body. Where the burden of parasites in the body is light, there may be ...