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Wilson's disease (also called hepatolenticular degeneration) is a genetic disorder characterized by the excess build-up of copper in the body. Symptoms are typically related to the brain and liver. Liver-related symptoms include vomiting, weakness, fluid build-up in the abdomen, swelling of the legs, yellowish skin, and itchiness.
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After weeks to years, joints and bones may become painful, fatigue may develop, and new skin lesions may appear. [6] The skin of the palms of the hands and the soles of the feet may become thick and break open. The bones (especially those of the nose) may become misshapen. After 5 years or more, large areas of skin may die, leaving scars. [6]
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Copper deficiency, or hypocupremia, is defined as insufficient copper to meet the body's needs, or as a serum copper level below the normal range. [1] Symptoms may include fatigue, decreased red blood cells, early greying of the hair, and neurological problems presenting as numbness, tingling, muscle weakness, and ataxia. [2]
Using moisturizers helps to improve skin comfort and may reduce disease flares. [ 13 ] [ 14 ] They can be used as leave-on treatments, bath additives, or soap substitutes . There are many different moisturizer products, but the majority of leave-on treatments (from least to most greasy) are one of the following: lotions, creams, gels, or ointments.
Atrophy refers to a loss of skin, and can be epidermal, dermal, or subcutaneous. [30] With epidermal atrophy, the skin appears thin, translucent, and wrinkled. [29] Dermal or subcutaneous atrophy is represented by depression of the skin. [29] Maceration: softening and turning white of the skin due to being consistently wet.
Symptoms of hypernatremia may vary depending on type and how quickly the electrolyte disturbance developed. [27] Common symptoms are dehydration, nausea, vomiting, fatigue, weakness, increased thirst, and excess urination. Patients may be on medications that caused the imbalance such as diuretics or nonsteroidal anti-inflammatory drugs. [27]
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