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  2. Clark's rule - Wikipedia

    en.wikipedia.org/wiki/Clark's_rule

    The procedure is to take the child's weight in pounds, divide by 150 lb, and multiply the fractional result by the adult dose to find the equivalent child dosage.For example, if an adult dose of medication calls for 30 mg and the child weighs 30 lb, divide the weight by 150 (30/150) to obtain 1/5 and multiply 1/5 times 30 mg to get 6 mg.

  3. Loading dose - Wikipedia

    en.wikipedia.org/wiki/Loading_dose

    In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose. [1] A loading dose is most useful for drugs that are eliminated from the body relatively slowly, i.e. have a long systemic half-life.

  4. Antibiotic-associated diarrhea - Wikipedia

    en.wikipedia.org/wiki/Antibiotic-associated_diarrhea

    Meta-analyses have concluded that probiotics may protect against antibiotic-associated diarrhea in both children and adults. [2] [3] Evidence is insufficient, however, regarding an effect on rates of C. difficile colitis. [4] The efficacy of probiotic AAD prevention is dependent on the probiotic strain(s) used and on the dosage.

  5. Laudanum - Wikipedia

    en.wikipedia.org/wiki/Laudanum

    The usual starting dose is 0.3 mL to 0.6 mL (about six to 12 drops) in a glass of water or juice four times a day. [31] Refractory cases (such as diarrhea resulting from the complications of HIV/AIDS) may require higher than normal dosing, for example, 1 to 2 mL every 3 hours, for a total daily dose of up to 16 mL a day. In terminal diseases ...

  6. Glycopeptide antibiotic - Wikipedia

    en.wikipedia.org/wiki/Glycopeptide_antibiotic

    Glycopeptide antibiotics are a class of drugs of microbial origin that are composed of glycosylated cyclic or polycyclic nonribosomal peptides.Significant glycopeptide antibiotics include the anti-infective antibiotics vancomycin, teicoplanin, telavancin, ramoplanin, avoparcin and decaplanin, corbomycin, complestatin and the antitumor antibiotic bleomycin.

  7. Drug of last resort - Wikipedia

    en.wikipedia.org/wiki/Drug_of_last_resort

    A drug of last resort (DoLR), also known as a heroic dose, [1] is a pharmaceutical drug which is tried after all other drug options have failed to produce an adequate response in the patient. Drug resistance , such as antimicrobial resistance or antineoplastic resistance , may make the first-line drug ineffective, especially in case of ...

  8. Volume of distribution - Wikipedia

    en.wikipedia.org/wiki/Volume_of_distribution

    Therefore, the dose required to give a certain plasma concentration can be determined if the V D for that drug is known. The V D is not a physiological value; it is more a reflection of how a drug will distribute throughout the body depending on several physicochemical properties, e.g. solubility, charge, size, etc.

  9. Chronic diarrhea of infancy - Wikipedia

    en.wikipedia.org/wiki/Chronic_diarrhea_of_infancy

    In pediatrics, diarrhea is a common complaint making up 9% of U.S. hospital visits for children less than 5 years old. [39] In contrast to resource-poor nations, resource-rich nations such as the United States experience less chronic diarrhea severity. In the United States, approximately a quarter of chronic diarrhea cases in young children ...