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The psychoactive effects of cannabis, known as a "high", are subjective and vary among persons and the method of use. When THC enters the blood stream and reaches the brain, it binds to cannabinoid receptors. The endogenous ligand of these receptors is anandamide, the effects of which THC emulates.
The anecdotal effects of 2C-B that have been reported by users on online discussion forums include: [20] [21] [22] At low doses, the experience may shift in intensity from engaging to mild/undetectable. Experienced users report the ability to take control of the effects and switch from engaged to sober at will.
Cannabis plants vary widely, with different strains producing dynamic balances of cannabinoids (THC, CBD, etc.) and yielding markedly different effects. Popular strains are often hybrids of C. sativa and C. indica. The medicinal effects of cannabis are widely studied, and are active topics of research both at universities and private research ...
It is speculated that this is due to neurotoxic effects of cannabis interfering with critical brain development. [16] [17] Chronic use of cannabis during adolescence, a time when the brain is still developing, is correlated in the long term with lower IQ and cognitive deficits.
Mescaline, also known as mescalin or mezcalin, [8] and in chemical terms 3,4,5-trimethoxyphenethylamine, is a naturally occurring psychedelic protoalkaloid of the substituted phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin.
The presence of these specialized cannabinoid receptors in the brain led researchers to the discovery of endocannabinoids, such as anandamide and 2-arachidonoyl glyceride . [citation needed] THC is a lipophilic molecule [27] and may bind non-specifically to a variety of entities in the brain and body, such as adipose tissue (fat).
The effects last for two to six hours, depending on the amount used. At high doses, mental effects can include anxiety, delusions (including ideas of reference), hallucinations, panic, paranoia, and psychosis. There is a strong relation between cannabis use and the risk of psychosis, though the direction of causality is debated.
Hashish (/ h ə ˈ ʃ iː ʃ / ⓘ; from Arabic ḥašiš 'hay'), usually abbreviated as hash, is a compressed form of resin (trichomes) derived from the marijuana flowers. [3] [4] As a psychoactive substance, it is consumed plain or mixed with tobacco.