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[37] [41] Worldwide, diarrhoeal disease, caused by cholera and many other pathogens, is the second-leading cause of death for children under the age of 5 and at least 120,000 deaths are estimated to be caused by cholera each year. [42] [43] In 2002, the WHO deemed that the case fatality ratio for cholera was about 3.95%. [37]
P. multocida causes a range of diseases in wild and domesticated animals, as well as humans. The bacterium is found in birds, cats , dogs, rabbits, cattle, and pigs. In birds, P. multocida causes avian or fowl cholera disease; a significant disease present in commercial and domestic poultry flocks worldwide, particularly layer flocks and parent ...
Cholera is caused by a number of types of Vibrio cholerae, with some types producing more severe disease than others. [2] It is spread mostly by unsafe water and unsafe food that has been contaminated with human feces containing the bacteria. [2] Undercooked shellfish is a common source. [9] Humans are the only known host for the bacteria. [2]
The following outline is provided as an overview of and topical guide to concepts related to infectious diseases in humans.. Infection – transmission, entry/invasion after evading/overcoming defense, establishment, and replication of disease-causing microscopic organisms (pathogens) inside a host organism, and the reaction of host tissues to them and to the toxins they produce.
This microscope slide, prepared by Pacini in 1854, was clearly identified as containing the cholera bacterium. Filippo Pacini (25 May 1812 – 9 July 1883) was an Italian anatomist, posthumously famous for isolating the cholera bacterium Vibrio cholerae in 1854, well before Robert Koch's more widely accepted discoveries 30 years later.
Factors which have been identified as impeding the identification of pathogens include the following: 1. Lack of animal models: Experimental infection in animals has been used as a criterion to demonstrate a disease-causing ability, but for some pathogens (such as Vibrio cholerae, which causes disease only in humans), animal models do not exist.
Koch's postulates are used to establish causal relationships between microbial pathogens and diseases. Whereas meningitis can be caused by a variety of bacterial, viral, fungal, and parasitic pathogens, cholera is only caused by some strains of Vibrio cholerae. Additionally, some pathogens may only cause disease in hosts with an immunodeficiency.
It has been known to cause serious disease in immunocompromised patients. [2] [3] Pasteurella was first described around 1880 and thought to be associated with chicken cholera and hemorrhagic septicemia in animals. The genus was first cultured in 1885. In 1920, strains of Pasteurella were isolated and observed in human infections. [1]