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Stick to creams and suppositories doctors trust, like Preparation H, “which can really offer a good amount of relief,” says Adegboyega, and temporarily shrink hemorrhoidal tissue.
There are increased side effects with sublingual or oral misoprostol, compared to a low dose (400 μg) vaginal misoprostol. However, low dose vaginal misoprostol was linked with low complete abortion rate. [42] The study concluded that sublingually administered misoprostol dosed at 600 μg or 400 μg had greater instances of fever and diarrhea ...
Misoprostol can also be used to manage duodenal ulcers and peptic ulcer disease when other medications are not effective. [7] It is on the World Health Organization's List of Essential Medicines for its obstetric uses. [8] Lubiprostone is a PGE 1 derivative used to treat chronic constipation. It is taken orally. [9]
Dinoprostone as a vaginal suppository is contraindicated for women with acute pelvic inflammatory disease or active disease of the cardiovascular, respiratory, hepatic, or renal systems. Caution is required for people with a history of cervical malignancy, hypo- or hypertension, anemia, epilepsy, jaundice, asthma, or pulmonary diseases.
The routes of administration include sublingual, oral, vaginal, and rectal with greatest efficacy from sublingual and vaginal administration. Vaginally administered misoprostol had improved outcomes of inducing labor within twenty four hours compared to oxytocin, but was associated with uterine hyperstimulation. [15]
Methotrexate is given either orally or intramuscularly, followed by vaginal misoprostol 3–5 days later. [22] The methotrexate combination is available through 63 days. The WHO authorizes the methotrexate-misoprostol combination [ 42 ] but recommends the mifepristone combination because methotrexate may be teratogenic to the embryo in cases of ...
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