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The DNA damage theory of aging postulates that DNA damage is ubiquitous in the biological world and is the primary cause of ageing. [27] The theory is based on the idea that ageing occurs over time due to the damage of the DNA. As an example, studies of mammalian brain and muscle have shown that DNA repair capability is relatively high during ...
In general, biological aging clocks and biomarkers of aging are expected to find many uses in biological research since age is a fundamental characteristic of most organisms. Accurate measures of biological age (biological aging clocks) could be useful for testing the validity of various theories of biological aging,
Genetic theories of aging propose that aging is programmed within each individual's genes. According to this theory, genes dictate cellular longevity. Programmed cell death, or apoptosis, is determined by a "biological clock" via genetic information in the nucleus of the cell. Genes responsible for apoptosis provide an explanation for cell ...
Biological aging explained ... Watching the clock. To test for biological age, ... for example, was about 12 years older than the rest of the body.
As women age, ovarian reserve -- which is defined as the quantity and the quality of the eggs remaining in the ovaries -- declines, and when all eggs are depleted, menopause starts and ...
The metabolic stability theory of aging suggests it is the cells ability to maintain stable concentration of ROS which is the primary determinant of lifespan. [37] This theory criticizes the free radical theory because it ignores that ROS are specific signalling molecules which are necessary for maintaining normal cell functions. [37]
Circadian clock, a molecular mechanism that results in a circadian rhythm in a living organism; Circadian rhythm, biological process that displays an oscillation about 24 hours, such as the human sleep-wake cycle (the "body clock") Epigenetic clock, a set of DNA sites whose methylation levels can be used to measure aging throughout the body
In biogerontology, the disposable soma theory of aging states that organisms age due to an evolutionary trade-off between growth, reproduction, and DNA repair maintenance. [1] Formulated by British biologist Thomas Kirkwood , the disposable soma theory explains that an organism only has a limited amount of resources that it can allocate to its ...