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Weight gain [18] There has been a study that suggests antipsychotics are associated with possible cortical reconfiguration and gray matter loss, [19] but correlational data also suggests patients who consume antipsychotics, like people with schizophrenia, tend to engage in unhealthy habits like smoking which may exacerbate gray matter loss. [20]
[67] [78] [79] [80] Some antipsychotic agents may be riskier than others during withdrawal, especially clozapine, olanzapine or low potency phenothiazines (e.g., chlorpromazine), as they lower the seizure threshold and can worsen withdrawal effects; if used, extreme caution is required.
Occasionally symptoms can last up to one year. [3] They typically resolve within a day of restoring the medication. [20] Paroxetine and venlafaxine seem to be particularly difficult to discontinue, and prolonged withdrawal syndrome (post-acute-withdrawal syndrome, or PAWS) lasting over 18 months has been reported with paroxetine. [21] [22] [23]
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One theory to explain antidepressant-related weight gain is that psychotropic medications such as antidepressants can affect neurotransmitters involved in eating behavior, causing an increase in ...
Weight gain (dose-dependent). Weight gain of over 7% of a person's initial body weight prior to treatment is in this category of very common too with some estimates of its incidence putting it at around 40.6%. This adverse effect is most likely the result of its potent 5-HT 2C receptor and H 1 receptor blockade (or more specifically inverse ...
The National Institutes of Health has a body weight planner that you can use to calculate your target food intake based on your optimal weight, age, height and activity level.
According to a 2013 meta-analysis of the comparative efficacy and tolerability of 15 antipsychotic drugs it was the most prone of the 15 for causing extrapyramidal side effects. [29] With more than 6 months of use 14 percent of users gain weight. [44] Haloperidol may be neurotoxic. [45] Prolonged use of the drug can lead to mental dependence. [46]