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A typical operon. In genetics, an operon is a functioning unit of DNA containing a cluster of genes under the control of a single promoter. [1] The genes are transcribed together into an mRNA strand and either translated together in the cytoplasm, or undergo splicing to create monocistronic mRNAs that are translated separately, i.e. several strands of mRNA that each encode a single gene product.
Applied to eukaryotes, the term refers to any group of non-contiguous genes controlled by the same regulatory gene. [ 2 ] A modulon is a set of regulons or operons that are collectively regulated in response to changes in overall conditions or stresses, but may be under the control of different or overlapping regulatory molecules.
Phylogenetic and symbiogenetic tree of living organisms, showing the origins of eukaryotes and prokaryotes. The two-empire system (two-superkingdom system) was the top-level biological classification system in general use from the early 20th century until the establishment of the three-domain system (which itself is currently being challenged by the two-domain system).
Gene structure is the organisation of specialised sequence elements within a gene.Genes contain most of the information necessary for living cells to survive and reproduce. [1] [2] In most organisms, genes are made of DNA, where the particular DNA sequence determines the function of the gene.
Eukaryotic transcription occurs within the nucleus where DNA is packaged into nucleosomes and higher order chromatin structures. The complexity of the eukaryotic genome necessitates a great variety and complexity of gene expression control. Eukaryotic transcription proceeds in three sequential stages: initiation, elongation, and termination. [1]
[15] [16] [17] Attenuation occurs at the start of some prokaryotic operons at sequences called "attenuators", which have been identified in operons encoding amino acid biosynthesis enzymes, pyrimidine biosynthesis enzymes and antibiotic resistance factors. The attenuator functions via a set of mRNA sequence elements that coordinate the status ...
Attenuators may be classified according to the type of molecule which induces the change in RNA structure. It is likely that transcription-attenuation mechanisms developed early, perhaps prior to the archaea/bacteria separation and have since evolved to use a number of different sensing molecules (the tryptophan biosynthetic operon has been found to use three different mechanisms in different ...
The origin of eukaryotes from Archaea, meaning the two are of the same larger group, came to be supported by studies based on ribosome protein sequencing and phylogenetic analyses in 2004. [ 30 ] [ 31 ] Phylogenomic analysis of about 6000 gene sets from 185 bacterial, archaeal and eukaryotic genomes in 2007 also suggested origin of eukaryotes ...