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The genomic variations have direct implications on the clinical symptoms of tick-borne Lyme disease. For example, the tick-borne Lyme disease caused by B. burgdorferi s.s. may manifest with arthritis-like symptoms. [9] In contrast, B. garinii’s tick-borne Lyme disease may cause an infection in the central nervous system. [9]
Borrelia burgdorferi is a bacterial species of the spirochete class in the genus Borrelia, and is one of the causative agents of Lyme disease in humans. [1] [2] Along with a few similar genospecies, some of which also cause Lyme disease, it makes up the species complex of Borrelia burgdorferi sensu lato.
Lyme disease, also known as Lyme borreliosis, is a tick-borne disease caused by species of Borrelia bacteria, transmitted by blood-feeding ticks in the genus Ixodes. [ 4 ] [ 9 ] [ 10 ] The most common sign of infection is an expanding red rash , known as erythema migrans (EM), which appears at the site of the tick bite about a week afterwards ...
Lyme disease is caused by infected black-legged (or deer) ticks and symptoms of the disease may vary, depending on how long it takes to discover the signs. Show comments Advertisement
Each copy of the gene, due to five adjacent nucleotide substitutions cause four amino acid changes and immunological subfunctionalization, [15] can be of one of two types: C4A and C4B. [16] Each gene contains 41 exons and has a dichotomous size variation between approximately 22 kb and 16 kb, with the longer variant being the result of the ...
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The binding of C2 and C4b results in C2 being cleaved by C1s into C2a and C2b. C2b diffuses into the plasma as a protein inflammatory mediator while C2a remains attached with C4b, forming the C3-convertase (C4b2a). The function of the membrane-bound C3-convertase is the cleavage of many many molecules of C3 into C3a and C3b.
According to the Mayo Clinic, Lyme disease is transmitted by ticks and caused by four species of bacteria in the United States, Europe and Asia. In fact, it’s the most common tick-borne illness ...