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Somatostatin is encoded by a CRE and is very susceptible to gene promoter region activation by transcription factor CREB. [1] There are five known somatostatin receptors: [2] SST 1 ; SST 2 ; SST 3 ; SST 4 ; SST 5 ; All are G protein-coupled seven transmembrane receptors.
An ancestral somatostatin gene was duplicated during the first whole-genome duplication event (1R) to create SS1 and SS2. These two genes were duplicated during the second whole-genome duplication event (2R) to create four new somatostatin genes:SS1, SS2, SS3, and one gene that was lost during the evolution of vertebrates.
20605 Ensembl ENSG00000139874 ENSMUSG00000035431 UniProt P30872 P30873 RefSeq (mRNA) NM_001049 NM_009216 RefSeq (protein) NP_001040 NP_033242 Location (UCSC) Chr 14: 38.21 – 38.21 Mb Chr 12: 58.26 – 58.26 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Somatostatin receptor type 1 is a protein that in humans is encoded by the SSTR1 gene. Function Somatostatin acts at many sites ...
Somatostatin receptor antagonists (or somatostatin inhibitors) are a class of chemical compounds that work by imitating the structure of the neuropeptide somatostatin. The somatostatin receptors are G protein-coupled receptors. Somatostatin receptor subtypes in humans are sstr1, 2A, 2 B, 3, 4 and 5. [1]
Somatostatin receptor subtypes in humans include sstr1, 2A, 2 B, 3, 4, and 5. [1] While normally expressed in the gastrointestinal (GI) tract, pancreas, hypothalamus, and central nervous system (CNS), [2] they are expressed in different types of tumours.
You can start with 3-pound dumbbells and move to 5, then 7, then 10 pounds over time, depending on the exercise,” says Sariya. (I've progressed from 3-pound dumbbells to 7 pounds over a few months.)
The radioactive octreotide attaches to tumor cells that have receptors for somatostatin (i.e. gastrinoma, glucagonoma, etc.). A gamma camera detects the radioactive octreotide, and makes pictures showing where the tumor cells are in the body, typically by a SPECT technique. A technetium-99m based radiopharmaceutical kit is also available. [2] [3]
The Doomsday clock was set at 89 seconds to midnight on Tuesday morning, putting it the closest the world has ever been to what scientists deem "global catastrophe."