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Ketamine provides an alternative to opiates for the treatment of acute pain. In a recent systematic review, low-dose ketamine was comparable to morphine in analgesic effectiveness within 60 minutes of administration, with comparable safety profiles, when used in the emergency department.
Ketamine therapy may help with chronic pain that doesn't respond to other treatments. Here's how it works and what to consider before trying it.
On the basis of a few short term trials with limited clinical applications, ketamine may be effective in the treatment of chronic peripheral and central neuropathic pain, phantom and ischemic limb pain, fibromyalgia, chronic regional pain syndrome (CRPS), visceral pain and migraine.
2. Ketamine for acute postoperative pain. There is a large body of literature addressing the use of ketamine in the perioperative setting. Adjuvant treatment with IV racemic, or S (+) ketamine is common, to improve postoperative pain relief and reduce opioid requirements.
The use of ketamine to treat chronic pain has been widely studied among several conditions, including complex regional pain syndrome, fibromyalgia, chronic neuropathic pain, post-thoracotomy pain, cancer pain, and phantom limb pain.
Among chronic pain patients, between 15% and 25% are estimated to have a predominantly neuropathic etiology. 29–31 For CRPS type I, which fails to meet the most recent International Association for the Study of Pain definition of neuropathic pain 32 but is the most common indication for ketamine treatment, the estimated prevalence rates vary ...
The latest data from the Centers for Disease Control and prevention estimates that 20% of US adults suffer from chronic pain, and 8% suffer from high impact chronic pain. Over the past two decades, intravenous ketamine infusion has become a popular treatment option for chronic pain.