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Cytokines (/ ˈ s aɪ t ə k aɪ n /) [1] are a broad and loose category of small proteins (~5–25 kDa [2]) important in cell signaling. Due to their size, cytokines cannot cross the lipid bilayer of cells to enter the cytoplasm and therefore typically exert their functions by interacting with specific cytokine receptors on the target
Chemokines (from Ancient Greek χῠμείᾱ (khumeíā) 'alchemy' and κῑ́νησῐς (kī́nēsis) 'movement'), or chemotactic cytokines, are a family of small cytokines or signaling proteins secreted by cells that induce directional movement of leukocytes, as well as other cell types, including endothelial and epithelial cells.
Some signaling molecules can function as both a hormone and a neurotransmitter. For example, epinephrine and norepinephrine can function as hormones when released from the adrenal gland and are transported to the heart by way of the blood stream. Norepinephrine can also be produced by neurons to function as a neurotransmitter within the brain. [18]
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An inflammatory cytokine is a type of cytokine (a signaling molecule) that is secreted from immune cells and certain other cell types that promotes inflammation. Inflammatory cytokines are predominantly produced by T helper cells ( T h ) and macrophages and involved in the upregulation of inflammatory reactions. [ 1 ]
Interleukin 3 (IL3) is a cytokine that regulates hematopoiesis by controlling the production, differentiation and function of granulocytes and macrophages. [15] [16] The protein, which exists in vivo as a monomer, is produced in activated T cells and mast cells, [15] [16] and is activated by the cleavage of an N-terminal signal sequence. [16]
Lymphokines are a subset of cytokines that are produced by a type of immune cell known as a lymphocyte. [1] They are protein mediators typically produced by T cells to direct the immune system response by signaling between its cells.
OSM is a pleiotropic cytokine that belongs to the interleukin 6 group of cytokines. [6] Of these cytokines it most closely resembles leukemia inhibitory factor (LIF) in both structure and function. [6] As yet poorly defined, it is proving important in liver development, haematopoeisis, inflammation and possibly CNS development. It is also ...