Search results
Results from the WOW.Com Content Network
Immortal cell lines of cancer cells can be created by induction of oncogenes or loss of tumor suppressor genes. One way to induce immortality is through viral -mediated induction of the large T-antigen , [ 10 ] commonly introduced through simian virus 40 (SV-40).
In their landmark paper, The Hallmarks of Cancer, [3] Hanahan and Weinberg suggest that cancer can be described by a small number of underlying principles, despite the complexities of the disease. The authors describe how tumor progression proceeds via a process analogous to Darwinian evolution, where each genetic change confers a growth ...
Isolation from a naturally occurring cancer. This is the original method for generating an immortalised cell line. A major example is human HeLa, a line derived from cervical cancer cells taken on February 8, 1951 from Henrietta Lacks, a 31-year-old African-American mother of five, who died of cancer on October 4, 1951. [6]
Oncogenomics is a sub-field of genomics that characterizes cancer-associated genes.It focuses on genomic, epigenomic and transcript alterations in cancer. Cancer is a genetic disease caused by accumulation of DNA mutations and epigenetic alterations leading to unrestrained cell proliferation and neoplasm formation.
Tissue can be organized in a continuous spectrum from normal to cancer. Often, the multiple genetic changes that result in cancer may take many years to accumulate. During this time, the biological behavior of the pre-malignant cells slowly changes from the properties of normal cells to cancer-like properties.
Now, new government-funded research has found even more potential health concerns to add to the list: Forever chemicals may raise the risk of developing ovarian cancer, melanoma and other types of ...
Typically, many genetic changes are required before cancer develops. [11] Approximately 5–10% of cancers are due to inherited genetic defects. [12] Cancer can be detected by certain signs and symptoms or screening tests. [2] It is then typically further investigated by medical imaging and confirmed by biopsy. [13]
Get AOL Mail for FREE! Manage your email like never before with travel, photo & document views. Personalize your inbox with themes & tabs. You've Got Mail!