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Pyramidal cells, or pyramidal neurons, are a type of multipolar neuron found in areas of the brain including the cerebral cortex, the hippocampus, and the amygdala. Pyramidal cells are the primary excitation units of the mammalian prefrontal cortex and the corticospinal tract .
The pyramidal cells in CA3 have a unique type of dendritic spine called a thorny excrescence or thorn, only found in CA3 pyramidal cells and hilar mossy cells. The thorn has a thin single spine with a number of heads. Clusters of thorns sit on a dendrite on a broad stem.
The trisynaptic circuit is a neural circuit in the hippocampus, which is made up of three major cell groups: granule cells in the dentate gyrus, pyramidal neurons in CA3, and pyramidal neurons in CA1. The hippocampal relay involves 3 main regions within the hippocampus which are classified according to their cell type and projection fibers.
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Of the six layers found within the neocortex, layer I is the most superficial and is composed of Cajal–Retzius cells and pyramidal cells. [8] This layer is unique in the aspect that these cells migrate to the outer edge of the cortex opposed to the migration experienced by the other 5 layers.
These perisomatic (around the cell body) and basal dendrites project into all cortical layers, but most of their horizontal branches/arbors populate layers V and VI, some reaching down into the white matter. [5] According to one study, Betz cells represent about 10% of the total pyramidal cell population in layer Vb of the human primary motor ...
These three layers are composed of pyramidal cells, cells that have a pyramidal shaped axon with long dendrites connecting to other cells in neighbouring columns. [ 5 ] The second section of the neomammalian brain is the Internal Granular Layer , and is known as layer four by neuroscientists; [ 10 ] this layer is responsible for receiving ...
Schaffer collaterals are the axons of pyramidal cells that connect two neurons (CA3 and CA1) and transfer information from CA3 to CA1. [5] [6] The entorhinal cortex sends the main input to the dentate gyrus (perforant pathway). From the granule cells of the dentate gyrus, connections are made to the CA3 regions of the hippocampus via mossy fibers.
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