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HIV encephalopathy; The presumptive criteria are designed for use where access to confirmatory diagnostic testing for HIV infection by means of virological testing (usually nucleic acid testing, NAT) or P24 antigen testing for infants and children aged under 18 months is not readily available.
WHO Disease Staging System for HIV Infection and Disease was first produced in 1990 by the World Health Organization [1] and updated in 2007. [2] It is an approach for use in resource limited settings and is widely used in Africa and Asia and has been a useful research tool in studies of progression to symptomatic HIV disease .
Unite for Children, Unite against AIDS is a global Campaign launched by UNICEF in 2005 to raise awareness of the plight of children globally in relation to HIV and AIDS, and to spur action. Almost every minute of every day, a child dies because of AIDS, and another two young people are infected with HIV. [ 1 ]
[18] [83] As of 2008, vertical transmission accounted for about 90% of cases of HIV in children. [84] In the absence of treatment, the risk of transmission before or during birth is around 20%, and in those who also breastfeed 35%. [84] Treatment decreases this risk to less than 5%. [85]
Standard anti-HIV IgG antibody tests cannot be used to reliably indicate a child's infection status before 18 months of age, so viral antigen tests are used. In the new system, HIV-infected children are classified into mutually exclusive categories according to three parameters: a) infection status b) clinical status c) immunologic status
HIV-infected women remain fertile, although in late stages of HIV disease a pregnant woman may have a higher risk of miscarriage. Normally, the risk of transmitting HIV to the unborn child is between 15 and 30%. However, this may be reduced to just 2–3% if patients carefully follow medical guidelines. [35] [36]
HIV tests have a high accuracy and the tests come in the form of antibody tests, antigen/antibody tests, and NATS (nucleic acid test). [32] There were approximately 38 million people across the globe with HIV/AIDS in 2019. Of these, 36.2 million were adults and 1.8 million were children under 15 years old. [33]
The risk of transmission from mother to child is proportional to the plasma viral load of the mother. Untreated mothers with a viral load >100,000 copies/ml have a transmission risk of over 50%. [65] The risk when viral loads are < 1000 copies/ml are less than 1%. [66]