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Human angiogenin diverged from ribonuclease, for example, and while the two paralogs remain similar in tertiary structure, their functions within the cell are now quite different. [ citation needed ] It is often asserted that orthologs are more functionally similar than paralogs of similar divergence, but several papers have challenged this notion.
Owen codified 3 main criteria for determining if features were homologous: position, development, and composition. In 1859, Charles Darwin explained homologous structures as meaning that the organisms concerned shared a body plan from a common ancestor, and that taxa were branches of a single tree of life .
Tail end of human embryo, from eight and a half to nine weeks old. 1 - 7: Homologous male and female pelvic organs. Diagrams that show the development of male and female organs from a common precursor.
DNA mismatch repair protein, MutS Homolog 3 (MSH3) is a human homologue of the bacterial mismatch repair protein MutS that participates in the mismatch repair (MMR) system. MSH3 typically forms the heterodimer MutSβ with MSH2 in order to correct long insertion/deletion loops and base-base mispairs in microsatellites during DNA synthesis.
229780 Ensembl ENSG00000122435 ENSMUSG00000033439 UniProt Q9NUP7 Q8BYH3 RefSeq (mRNA) NM_019083 NM_001393409 NM_001393410 NM_001393411 NM_001393412 NM_001393413 NM_001393414 NM_030016 RefSeq (protein) NP_061956 NP_084292 Location (UCSC) Chr 1: 100.13 – 100.15 Mb Chr 3: 116.37 – 116.41 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse TRNA methyltransferase 13 homolog is a protein ...
Wings apart-like protein homolog (WAPL) is a protein that in humans is encoded by the WAPAL gene. [ 5 ] [ 6 ] [ 7 ] WAPL is a key regulator of the Cohesin complex which mediates sister chromatid cohesion , homologous recombination and DNA looping .
66164 Ensembl ENSG00000132603 ENSMUSG00000031917 UniProt Q9Y221 Q9CXK8 RefSeq (mRNA) NM_016101 NM_001199434 NM_001164472 NM_025391 RefSeq (protein) NP_001186363 NP_057185 NP_001157944 NP_079667 Location (UCSC) Chr 16: 69.34 – 69.34 Mb Chr 8: 107.78 – 107.79 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse 60S ribosome subunit biogenesis protein NIP7 homolog is a protein that in ...
109115 Ensembl ENSG00000196284 ENSMUSG00000038954 UniProt O75486 n/a RefSeq (mRNA) NM_001261823 NM_003599 NM_181356 NM_001350324 NM_001350325 NM_001350326 NM_001350327 NM_001350329 NM_178652 NM_001357320 RefSeq (protein) NP_001248752 NP_003590 NP_852001 NP_001337253 NP_001337254 NP_001337255 NP_001337256 NP_001337258 n/a Location (UCSC) Chr 6: 44.81 – 45.38 Mb Chr 17: 45.09 – 45.43 Mb ...
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