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Dopamine agonists are currently the preferred medication for suppressing lactation, which work by suppressing prolactin production. [3] Cabergoline (Dostinex™) is currently most effective option currently available, as it is available as a single dose (as opposed to bromocriptine which must be taken twice daily for 2 weeks.) [4] It may be prescribed in the case of breast abscess.
During lactation, breast abscess develops only rarely, most sources cite about 0.4–0.5% of breastfeeding women. [8] Known risk factors are age over 30, primiparous (first birth) and late delivery. No correlation was found with smoking status; however, this may be in part because far fewer smoking women choose to breastfeed. [15]
While patients are able to use these resources as well, they are targeted toward medical professionals. Patients should be encouraged to consult a lactation specialist or a medical provider trained in breastfeeding medicine if any concerns arise. Two helpful resources are listed below. LactMed @ NIH (Drugs and Lactation Database (LactMed)) [161]
A galactagogue, or galactogogue (from Greek: γάλα [γαλακτ-], milk, + ἀγωγός, leading), also known as a lactation inducer or milk booster, is a substance that promotes lactation in humans and other animals. [1] [2] It may be synthetic, plant-derived, or endogenous. They may be used to induce lactation and to treat low milk supply.
Because of these risks, the FDA strongly cautions against the use of domperidone to enhance lactation. [34] A review by Health Canada also found a link between the sudden discontinuation or tapering of domperidone when used off-label for lactation, and psychiatric withdrawal events, particularly daily doses greater than the maximum recommended ...
For example, she may have a chronic or acute illness, and either the illness itself, or the treatment for it, reduces or stops her milk. This absence of lactation may be temporary or permanent. There was a greater need for wet nurses when the rates of infant abandonment and maternal death, during and shortly after childbirth, were high.
Prolactin has a wide variety of effects. It stimulates the mammary glands to produce milk (): increased serum concentrations of prolactin during pregnancy cause enlargement of the mammary glands and prepare for milk production, which normally starts when levels of progesterone fall by the end of pregnancy and a suckling stimulus is present.
[1] [53] [54] A systematic review and meta-analysis has shown that cabergoline and quinagolide are more effective in the treatment of hyperprolactinemia compared to bromocriptine, [55] this is because evidence had suggested fewer side effects, rapid titration and offers better dosing interval in medication like quinagolide compared to ...