Search results
Results from the WOW.Com Content Network
An epigenetic clock is a biochemical test that can be used to measure age. The test is based on modifications that change over time and regulate how genes are expressed. Typically they can use DNA methylation levels, measuring the accumulation of methyl groups to one's DNA molecules, or more recently, based on the histone
Steve Horvath is a German–American aging researcher, geneticist, and biostatistician.He is a professor at the University of California, Los Angeles known for developing the Horvath aging clock, which is a highly accurate molecular biomarker of aging, and for developing weighted correlation network analysis.
Certain factors can accelerate the epigenetic clock, including smoking, unhealthy eating, a sedentary lifestyle and "pretty much any lifestyle factor that is bad for you," Horvath said.
The first published epigenetic clock that used DNA methylation to predict chronological age came from the Bocklandt group in 2011. [9] This clock was generated with saliva samples and was based on 3 CpGs found in 3 gene promoters (EDARADD, TOM1L1, and NPTX2). Two years later, Steve Horvath generated epigenetic clocks for 51 different tissues ...
The epigenetic clock is a promising biomarker of aging and can accurately predict human chronological age. [6] Basic blood biochemistry and cell counts can also be used to accurately predict the chronological age. [ 7 ]
English: Comparison of the 3 age predictors described in A) Horvath (2013, PubMed identifier 24138928), B) Hannum (2013, PMID: 23177740), and C) Weidener (2014, PMID: 24490752), respectively. The x-axis depicts the chronological age in years whereas the y-axis shows the predicted age.
Other cool features of this mid-priced sunset alarm clock are the variable duration of the sunrise or sunset simulations (20, 30, or 45 minutes), a light-sensitive clock display that brightens ...
Multiple epigenetic age estimators exist. Horvath's clock measures a multi-tissue set of 353 CpGs, half of which positively correlate with age, and the other half negatively, to estimate the epigenetic age. [27] Hannum's clock utilizes adult blood samples to calculate age based on an orthogonal basis of 71 CpGs. [28] Levine's clock, known as ...