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MUltiple Sequence Comparison by Log-Expectation (MUSCLE) is a computer software for multiple sequence alignment of protein and nucleotide sequences. It is licensed as public domain. The method was published by Robert C. Edgar in two papers in 2004. The first paper, published in Nucleic Acids Research, introduced the sequence alignment algorithm ...
Multiple sequence alignment (MSA) is the process or the result of sequence alignment of three or more biological sequences, generally protein, DNA, or RNA. These alignments are used to infer evolutionary relationships via phylogenetic analysis and can highlight homologous features between sequences.
In bioinformatics, MAFFT (multiple alignment using fast Fourier transform) is a program used to create multiple sequence alignments of amino acid or nucleotide sequences. . Published in 2002, the first version used an algorithm based on progressive alignment, in which the sequences were clustered with the help of the fast Fourier transfo
Quality control and filtering of multiple sequence alignments: Both: Local or global: O. Penn et al. 2010 (latest version 2015) Kalign Progressive alignment: Both: Global: T. Lassmann: 2005: MACSE Progressive-iterative alignment. Multiple alignment of coding sequences accounting for frameshifts and stop codons. Nucleotides Global V. Ranwez et al.
M-Coffee: a special mode of T-Coffee that makes it possible to combine the output of the most common multiple sequence alignment packages (Muscle, ClustalW, Mafft, ProbCons, etc.). The resulting alignments are slightly better than the individual one, but most importantly the program indicates the alignment regions where the various packages ...
Clustal Omega, ClustalW2, MAFFT, MUSCLE, BioJava are integrated to construct alignment Tree calculation tool calculates phylogenetic tree using BioJava API and lets user draw trees using Archaeopteryx: Software is package of 7 interactive visual tools for multiple sequence alignments. Major focus is manipulating large alignments.
Progressive multiple sequence alignment: Distance matrix/nearest neighbor: Thompson et al. [13] CoalEvol Simulation of DNA and protein evolution along phylogenetic trees (that can also be simulated with the coalescent) Simulation of multiple sequence alignments of DNA or protein sequences M. Arenas, D. Posada CodABC
In bioinformatics and proteomics, ProbCons is an open source software for probabilistic consistency-based multiple alignment of amino acid sequences. It is one of the most efficient protein multiple sequence alignment programs, since it has repeatedly demonstrated a statistically significant advantage in accuracy over similar tools, including Clustal and MAFFT.