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Serious side effects may include allergic reactions and heart failure. [3] Use is not recommended in those with asthma, a sulfonamide allergy, or a slow heart rate. [3] [7] Dorzolamide is a carbonic anhydrase inhibitor and timolol is a beta blocker. [3] Both work by decreasing the amount of aqueous humor made by the eye. [3]
The most common side effect is conjunctival hyperaemia (increased bloodflow in the outer layer of the eye), which occurs in over 10% of people taking the drug. Side effects in less than 10% of people include other eye problems such as itching, foreign body sensation or dry eye, as headache or hyperpigmentation (darkening) of the skin around the eye.
Side effects are similar to other prostaglandin analogs applied to the eye. The most common one is conjunctival hyperemia , which occurs in more than 10% of patients. Other effects include blurred vision, eye and eyelid redness, eye burning or other discomfort, and permanent darkening of the iris to brown.
Hair loss is a well-known side effect of many chemotherapy drugs used to treat certain forms of cancer. Similar to other toxins that cause hair loss, hair loss from cancer medications usually isn ...
A separate study, published in the Journal of the American Academy of Dermatology looked at the effects of topical minoxidil in men with pattern hair loss over a total treatment period of 48 weeks.
The cause of a stye is usually a bacterial infection by Staphylococcus aureus. [3] [6] Internal styes are due to infection of the meibomian gland while external styes are due to an infection of the gland of Zeis. [5] A chalazion on the other hand is a blocked meibomian gland without infection. [4]
Side effects from DHT blockers used in hair loss prevention shampoos are also uncommon. Some ingredients may cause irritation, dry skin, itchy skin or other similarly minor effects.
The most important factor that must be taken into account when designing any type of drug delivery device, and specifically ocular devices, is the release rate of a drug. As discussed previously, the deliver rate and kinetics associated with drugs to the eye can reach levels that are toxic to the eye or could even cause undesirable side effects.
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