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Most cases are treated by application of topical antifungal creams to the skin, but in extensive or difficult to treat cases, systemic treatment with oral medication may be required. The over-the-counter options include tolnaftate, as well as ketoconazole (available as Nizoral shampoo that can be applied topically). [citation needed]
The general mechanism of action for topical antifungal drugs is the disruption of the cell membrane. The unique components found in fungal cell membranes are usually the drug targets of antifungal drugs, in particular ergosterol. It is a sterol, which is important in maintaining proper membrane fluidity and normal functions of the cell membrane.
Tolnaftate [1] sold under the brand name TAGRID among, others is a synthetic thiocarbamate used as an anti-fungal agent that may be sold without medical prescription in most jurisdictions. It is supplied as a cream, powder, spray, liquid, and liquid aerosol . [ 2 ]
Tinea corporis (also known as "ringworm", [2] tinea circinata, [11] and tinea glabrosa [2]) is a superficial fungal infection (dermatophytosis) of the arms and legs, especially on glabrous skin; however, it may occur on any part of the body, it present as annular, marginated plaque with thin scale and clear center.
Like the allylamine antifungals (e.g terbinafine), butenafine works by inhibiting the synthesis of ergosterol by binding to and inhibiting squalene epoxidase, an enzyme in the pathway used for creation of the sterols needed in fungal cell membranes. Lacking ergosterol, the cell membranes increase in permeability, allowing their contents to leak ...
From allergies to athlete's foot, headaches to heartburn, ringworm to rashes, Perrigo Pharmaceuticals (NAS: PRGO) has a treatment. Perrigo's vast portfolio of generic drugs helped the company wrap ...
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