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The rhesus monkeys were split into a test group and into a control group. The test group was administered orexin-A, intravenously or nasally. The control group was given a placebo. The sleep-deprived monkeys which were given the nasal form of orexin-A performed far better than the ones treated with injections.
Orexin (/ ɒ ˈ r ɛ k s ɪ n /), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. [5] It exists in the forms of orexin-A and orexin-B.The most common form of narcolepsy, type 1, in which the individual experiences brief losses of muscle tone ("drop attacks" or cataplexy), is caused by a lack of orexin in the brain due to destruction of the cells ...
Narcolepsy is a chronic neurological disorder that impairs the ability to regulate sleep–wake cycles, and specifically impacts REM (rapid eye movement) sleep. [1] The pentad symptoms of narcolepsy include excessive daytime sleepiness (EDS), sleep-related hallucinations, sleep paralysis, disturbed nocturnal sleep (DNS), and cataplexy. [1]
The orexin receptor (also referred to as the hypocretin receptor) is a G-protein-coupled receptor that binds the neuropeptide orexin. There are two variants, OX 1 and OX 2 , each encoded by a different gene ( HCRTR1 , HCRTR2 ).
230777 Ensembl ENSG00000121764 ENSMUSG00000028778 UniProt O43613 P58307 RefSeq (mRNA) NM_001525 NM_001163027 NM_198959 NM_001305392 NM_001357258 RefSeq (protein) NP_001516 NP_001156499 NP_001292321 NP_945197 NP_001344187 Location (UCSC) Chr 1: 31.62 – 31.63 Mb Chr 4: 130.02 – 130.03 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Orexin receptor type 1 (Ox1R or OX 1), also known ...
2. Excessive Stress. Stress is a natural, normal part of the human experience, and your body knows how to handle it. When you’re under stress, your body releases stress hormones that activate ...
Orexin receptor type 2 (Ox2R or OX 2), also known as hypocretin receptor type 2 (HcrtR2), is a protein that in humans is encoded by the HCRTR2 gene. [5] It should not be confused for the protein CD200R1 which shares the alias OX2R but is a distinct, unrelated gene located on the human chromosome 3.
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