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Similarly, both dual-specificity MAP kinase phosphatases and MAP-specific tyrosine phosphatases bind to MAP kinases through the same docking site. [34] [35] D-motifs can even be found in certain MAPK pathway regulators and scaffolds (e.g. in the mammalian JIP proteins). [citation needed] Other, less well characterised substrate-binding sites ...
This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells.
The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAP kinase) family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals.
The effects of Akt activation on Cell Cycle progression. Akt promotes G1-S phase cell cycle progression by phosphorylating and inactivating glycogen synthase kinase 3 (GSK-3) at Ser9. This prevents the phosphorylation and degradation of cyclin D1. [31] Therefore, Akt promotes G1 phase progression in a positive feedback loop.
26403 Ensembl ENSG00000173327 ENSMUSG00000004054 UniProt Q16584 Q80XI6 RefSeq (mRNA) NM_002419 NM_022012 RefSeq (protein) NP_002410 NP_002410.1 NP_071295 Location (UCSC) Chr 11: 65.6 – 65.62 Mb Chr 19: 5.74 – 5.75 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mitogen-activated protein kinase kinase kinase 11 is an enzyme that in humans is encoded by the MAP3K11 gene. Function ...
MAP3K1 is highly conserved in Euteleostomi. [19] The spontaneous recessive lidgap-Gates mutation (deletion of Map3k1 exons 2–9, initially described in the 1960s) identified on the SELH/Bc mouse strain causes the same open-eyelids-at-birth mutational phenotype as the gene knockout mutations of the mouse (but not human) MAP3K1 homolog (Map3k1) and also co-maps to distal Chromosome 13. [20]
26415 Ensembl ENSG00000156711 ENSMUSG00000004864 UniProt O15264 Q9Z1B7 RefSeq (mRNA) NM_002754 NM_011950 RefSeq (protein) NP_002745 NP_036080 Location (UCSC) Chr 6: 36.13 – 36.14 Mb Chr 17: 28.99 – 29 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mitogen-activated protein kinase 13 (MAPK 13), also known as stress-activated protein kinase 4 (SAPK4), is an enzyme that in humans ...
26397 Ensembl ENSG00000034152 ENSMUSG00000018932 UniProt P46734 O09110 RefSeq (mRNA) NM_002756 NM_145109 NM_145110 NM_001316332 NM_008928 RefSeq (protein) NP_001303261 NP_002747 NP_659731 NP_032954 Location (UCSC) Chr 17: 21.28 – 21.32 Mb Chr 11: 60.82 – 60.84 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme ...