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An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells. The part of an antibody that binds to the epitope is called a paratope .
T cell epitope content is one of the factors that contributes to antigenicity. Likewise, T Cell epitopes can cause unwanted immunogenicity, including the development of ADAs. A key determinant in T cell epitope immunogenicity is the binding strength of T cell epitopes to major histocompatibility complexes (MHC or HLA) molecules. Epitopes with ...
Epitope – the distinct surface features of an antigen, its antigenic determinant. Antigenic molecules, normally "large" biological polymers, usually present surface features that can act as points of interaction for specific antibodies. Any such feature constitutes an epitope.
He defined idiotype as the set of epitopes on the V region of an antibody molecule, where epitope means an antigenic determinant. He also defined the " paratope " to be that part of an antibody variable region that binds to an antigen.
The antigenic determinant or epitope is recognized by the paratope of the antibody, situated at the variable region of the polypeptide chain. The variable region in turn has hyper-variable regions which are unique amino acid sequences in each antibody.
Epitopes, also referred to as antigenic determinants, are parts of an antigen that are recognized by the immune system. A neoepitope is an epitope the immune system has not encountered before. Therefore it is not subject to tolerance mechanisms of the immune system. [4]
This site binds to a portion of the antigen called an antigenic determinant or epitope. The binding, like that between an enzyme and its substrate, depends on complementarity of the surface of the receptor and the surface of the epitope and occurs mainly by non-covalent forces. Successful binding of the antigen receptor to the epitope, if ...
In immunology, an idiotope is the unique set of antigenic determinants (epitopes) of the variable portion of an antibody. [1] In some cases it can be the actual antigen-binding site, and in some cases it may comprise variable region sequences outside of the antigen-binding site on the antibody itself.