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BAD is a pro-apoptotic protein of the Bcl-2 family. Akt1 can phosphorylate BAD on Ser136, [21] which makes BAD dissociate from the Bcl-2/Bcl-X complex and lose the pro-apoptotic function. [22] Akt1 can also activate NF-κB via regulating IκB kinase (IKK), thus result in transcription of pro-survival genes. [23]
The Research Organization for Life Sciences and Environment (Indonesian: Organisasi Riset Ilmu Pengetahuan Hayati dan Lingkungan, ORIPHL but also known as ORHL) is one of Research Organizations under the umbrella of the National Research and Innovation Agency (Badan Riset dan Inovasi Nasional, BRIN).
The Research Organization for Health (Indonesian: Organisasi Riset Kesehatan, OR Kesehatan) is one of Research Organizations under the umbrella of the National Research and Innovation Agency (Badan Riset dan Inovasi Nasional, BRIN).
Transcobalamin I (TC-1), also known as haptocorrin (HC), R-factor, and R-protein is encoded in the human by the TCN1 gene. TC-1 is a glycoprotein produced by the salivary glands of the mouth. It primarily serves to protect cobalamin (Vitamin B12) from acid degradation in the stomach by producing a HC-Vitamin B 12 complex.
The IκB kinase enzyme complex is part of the upstream NF-κB signal transduction cascade. The IκBα (inhibitor of nuclear factor kappa B) protein inactivates the NF-κB transcription factor by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm.
Kinesin is a protein functioning as a molecular biological machine. It uses protein domain dynamics on nanoscales. A protein complex or multiprotein complex is a group of two or more associated polypeptide chains. Protein complexes are distinct from multidomain enzymes, in which multiple catalytic domains are found in a single polypeptide chain ...
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The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex is a protein complex responsible for the regulation of cell cycle-dependent gene expression. [ 1 ] [ 2 ] The complex is evolutionarily conserved, although some of its components vary from species to species.
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