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Common sites for squamous metaplasia include the bladder and cervix. Smokers often exhibit squamous metaplasia in the linings of their airways. These changes don't signify a specific disease, but rather usually represent the body's response to stress or irritation. Vitamin A deficiency or overdose can also lead to squamous metaplasia. [1]
Reactive gastropathy, is characterized histologically by: [2] - Foveolar hyperplasia (black arrow), as a tortuosity in the "neck" region of the gastric glands. - Scant or minimal inflammatory cells (white arrow), i.e. lack of large numbers of neutrophils and plasma cells.. - Smooth muscle hyperplasia in the lamina propria (in black oval).
Chronic inflammation caused by H. pylori infection in the stomach and GERD in the esophagus are seen as the primary instigators of metaplasia and subsequent adenocarcinoma formation. Initially, the transformed epithelium resembles the small intestine lining; in the later stages it resembles the lining of the colon.
Barrett's esophagus is an abnormal change in the cells of the lower esophagus, thought to be caused by damage from chronic stomach acid exposure. The following table lists some common tissues susceptible to metaplasia, and the stimuli that can cause the change:
Micrograph of Barrett's esophagus (left of image) and normal stratified squamous epithelium (right of image). Alcian blue stain.. Glandular metaplasia is a type of metaplasia where irritated tissue converts to a glandular form.
For instance, mucosa in the stomach protects it from stomach acid, [2]: 384, 797 and mucosa lining the bladder protects the underlying tissue from urine. [8] In the uterus, the mucous membrane is called the endometrium, and it swells each month and is then eliminated during menstruation. [2]: 1019
Microglandular hyperplasia (MGH) of the cervix is an epithelial (endocervical mucosa) benign abnormality (lesion) associated with gland proliferation. [1] [2] It can terminate in mature squamous metaplasia, and it is suspected reserve cells are involved in this process, perhaps in the form of reserve cell hyperplasia with glandular differentiation.
Pseudomyxoma peritonei (PMP) is a clinical condition caused by cancerous cells (mucinous adenocarcinoma) that produce abundant mucin or gelatinous ascites. [1] The tumors cause fibrosis of tissues and impede digestion or organ function, and if left untreated, the tumors and mucin they produce will fill the abdominal cavity.