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With lytic phages such as the T4 phage, bacterial cells are broken open (lysed) and destroyed after immediate replication of the virion. As soon as the cell is destroyed, the phage progeny can find new hosts to infect. [15] Lytic phages are more suitable for phage therapy. Some lytic phages undergo a phenomenon known as lysis inhibition, where ...
Assembled major coat protein, exploded view. The virion is a flexible filament (worm-like chain) about 6 nm in diameter and 900 nm long.Several thousand copies of a small (50 amino-acid residues) elongated alpha-helical major coat protein subunit (the product of gene 8, or p8) in an overlapping shingle-like array form a hollow cylinder enclosing the circular single-stranded DNA genome.
An MS2 virion (viral particle) is about 27 nm in diameter, as determined by electron microscopy. [4] It consists of one copy of the maturation protein and 180 copies of the coat protein (organized as 90 dimers ) arranged into an icosahedral shell with triangulation number T=3 , protecting the genomic RNA inside. [ 5 ]
In order for the T-even phage to infect its host and begin its life cycle it must enter the first process of infection, adsorption of the phage to the bacterial cell. Adsorption is a value characteristic of phage-host pair and the adsorption of the phage on host cell surface is illustrated as a 2-stage process: reversible and irreversible.
Assembled major coat protein subunits in Ff (fd, f1, M13) filamentous bacteriophage (genus Inovirus), exploded view. Filamentous phage virion--schematic views. Filamentous bacteriophages are among the simplest living organisms known, with far fewer genes than the classical tailed bacteriophages studied by the phage group in the mid-20th century.
There are three classes of genes in the phage genome that regulate whether the lytic or lysogenic cycles will emerge. The first class is the immediate early genes, the second is the delayed early genes and the third is the late genes. The following refers to the well-studied temperate phage lambda of E. coli. [citation needed]
Structure of phage ΦX174 capsid Schematic drawing of a Sinsheimervirus (aka Phix174microvirus) virion. The phi X 174 (or ΦX174) bacteriophage is a single-stranded DNA virus that infects Escherichia coli.
CTXφ is generally present and integrated into the genome of the V. cholerae bacterium, and more rarely in a virion from outside the bacterium. While integrated into the bacterial genome, CTX prophages are found on each of the two chromosomes (in the O1 serogroup of V. cholerae) or arranged in tandem on the larger chromosome (in the El Tor biotype of V. cholerae). [2]