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The neuraxis or sometimes neuroaxis [1] is the axis of the central nervous system.It denotes the direction in which the central nervous system lies. During embryological development, the neuraxis is bent by various flexures, contributing to the mature structure of the brain and spinal cord.
Neurulation refers to the folding process in vertebrate embryos, which includes the transformation of the neural plate into the neural tube. [1] The embryo at this stage is termed the neurula . The process begins when the notochord induces the formation of the central nervous system (CNS) by signaling the ectoderm germ layer above it to form ...
This process is known as neurulation. [8] When the tube is closed at both ends it is filled with embryonic cerebrospinal fluid. [9] As the embryo develops, the anterior part of the neural tube expands and forms three primary brain vesicles, which become the forebrain (prosencephalon), midbrain (mesencephalon), and hindbrain (rhombencephalon).
The human brain is the central organ of the nervous system, and with the spinal cord, comprises the central nervous system.It consists of the cerebrum, the brainstem and the cerebellum.
The neural tube has a longitudinal axis called the neuraxis, from the future brain area at the cranial end, to the conus medullaris of the spinal cord at the caudal end. By the fourth week in the human embryo, at its cranial end, three swellings have formed as primary brain vesicles. [1]
The resultant patterning along the neuraxis leads to segmentation of the neuroepithelium into progenitor domains (p0, p1 p2, p3 and pMN) for distinct neuron types in the developing spinal cord. On the basis of several studies it is now believed that this model also applies to macroglial cell specification.
Congenital dermal sinus is an uncommon form of cranial or spinal dysraphism. [2] [3] It occurs in 1 in 2500 live births. [3]It occurs as a dermal indentation, found along the midline of the neuraxis and often presents alongside infection and neurological deficit. [2]
Adult neurogenesis is the process in which neurons are generated from neural stem cells in the adult. This process differs from prenatal neurogenesis. In most mammals, new neurons are born throughout adulthood in two regions of the brain: [3]