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Benzatropine , [2] known as benztropine in the United States and Japan, [3] is a medication used to treat movement disorders like parkinsonism and dystonia, as well as extrapyramidal side effects of antipsychotics, including akathisia. [4] It is not useful for tardive dyskinesia. [4] It is taken by mouth or by injection into a vein or muscle. [4]
The onset of action is within 1 hour after oral dosing. The peak activity is noted after 2 to 3 hours. [24] The duration of action of one single dose is 6 to 12 hours in a dose dependent manner. It is excreted in the urine, probably as unchanged drug. More precise data in animals and humans have so far not been determined. [25] [26]
Onset of action is the duration of time it takes for a drug's effects to come to prominence upon administration. With oral administration , it typically ranges anywhere from 20 minutes to over an hour, depending on the drug in question.
Benztropine: M1-selective PD; EPS caused by typical and atypical antipsychotics; Reduces the effects of the relative central cholinergic excess that occurs as a result of dopamine deficiency. Cogentin Cyclopentolate: NS: produce mydriasis and cycloplegia in diagnostics [5] may cause ocular hypertension [5] Short acting, CD [5] Diphenhydramine: NS
Its mechanism of action is not entirely clear but is believed to be related to its ability as a dopamine antagonist. [6] It has antiserotonergic and antihistaminergic properties. [6] Common side effects include movement problems, sleepiness, dry mouth, low blood pressure upon standing, and increased weight. [6]
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