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Smoking: Recent studies [14] suggest that smoking can lead to marginal biotin deficiency because it speeds up biotin catabolism (especially in women). [19] Excessive alcohol consumption [20] (causes a significant reduction in plasma biotin levels) Excessive consumption of antidiuretics or inadequate levels of antidiuretic hormone [21]
One important note: Excess biotin can also "cause incorrect results in certain laboratory tests that look at thyroid levels and blood markers that can help diagnose heart attacks," says Dr. Castillo.
The standard treatment regimen calls for 5–10 mg of biotin per day. [ 6 ] Biotinidase deficiency is inherited in an autosomal recessive pattern, which means the defective gene is located on an autosome , and two copies of the defective gene - one from each parent - must be inherited for a person to be affected by the disorder.
Biotin, a B vitamin, is found in foods such as liver, egg yolks, and milk. It is essential for the normal production and breakdown of proteins, fats, and carbohydrates in the body. Mutations in the HLCS gene reduce the activity of holocarboxylase synthetase, preventing cells from using biotin effectively and disrupting many cellular functions.
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Biotin is stable at room temperature and is not destroyed by cooking. The dietary biotin intake in Western populations has been estimated to be in the range of 35 to 70 μg/day. Nursing infants ingest about 6 μg/day. [4] Biotin is available in dietary supplements, individually or as an ingredient in multivitamins. [1] [3]
Hypervitaminosis is a condition of abnormally high storage levels of vitamins, which can lead to various symptoms as over excitement, irritability, or even toxicity. Specific medical names of the different conditions are derived from the given vitamin involved: an excess of vitamin A , for example, is called hypervitaminosis A .