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Tuberculosis (TB) vaccines are vaccinations intended for the prevention of tuberculosis.Immunotherapy as a defence against TB was first proposed in 1890 by Robert Koch. [1] As of 2021, the only effective tuberculosis vaccine in common use is the Bacillus Calmette-Guérin (BCG) vaccine, first used on humans in 1921.
MVA85A (modified vaccinia Ankara 85A) is a vaccine against tuberculosis developed by researchers led by Professor Helen McShane at Oxford University. [1] It is a viral vector vaccine and consists of an MVA virus engineered to express the 85A antigen once it infects a host cell. 85A is a cell-wall protein of the tuberculosis bacillus.
The Bacillus Calmette–Guérin (BCG) vaccine is a vaccine primarily used against tuberculosis (TB). [9] It is named after its inventors Albert Calmette and Camille Guérin. [10] [11] In countries where tuberculosis or leprosy is common, one dose is recommended in healthy babies as soon after birth as possible. [9]
In 2017, the country with the highest estimated incidence rate as a % of the population was Lesotho, with 665 cases per 100,000 people. [190] In South Africa, 54,200 people died in 2022 from TB. The incidence rate was 468 per 100,000 people; in 2015, this was 988 per 100,000. The total incidence was 280,000 in 2022; in 2015, this was 552,000. [191]
South Africa, one of the world's most unequal countries with a large population vulnerable to the new coronavirus, may have an advantage in the outbreak, honed during years battling HIV and ...
In contemporary South Africa, Boer and Afrikaner have often been used interchangeably. [dubious – discuss] Afrikaner directly translated means African, and thus refers to all Afrikaans-speaking people in Africa who have their origins in the Cape Colony founded by Jan Van Riebeeck. Boer is a specific group within the larger Afrikaans-speaking ...
Luckily, the BCG vaccine was developed, which prevents TB meningitis and miliary TB in childhood. But, the vaccine does not provide substantial protection against the more virulent forms of TB found among adults. Most forms of TB can be treated with antibiotics to kill the bacteria. The two antibiotics most commonly used are rifampicin and ...
The TB-free New Zealand programme is regarded as "world-leading". [12] It has successfully reduced cattle- and deer-herd infection rates from more than 1700 in 1994 to fewer than 100 herds in July 2011. Much of this success can be attributed to sustained cattle controls reducing cross-infection and breaking the disease cycle.