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  2. Orexin - Wikipedia

    en.wikipedia.org/wiki/Orexin

    Orexin (/ ɒ ˈ r ɛ k s ɪ n /), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. [5] It exists in the forms of orexin-A and orexin-B.The most common form of narcolepsy, type 1, in which the individual experiences brief losses of muscle tone ("drop attacks" or cataplexy), is caused by a lack of orexin in the brain due to destruction of the cells ...

  3. Appetite stimulant - Wikipedia

    en.wikipedia.org/wiki/Appetite_stimulant

    Appetite stimulant. An orexigenic, or appetite stimulant, is a drug, hormone, or compound that increases appetite and may induce hyperphagia. This can be a medication or a naturally occurring neuropeptide hormone, such as ghrelin, orexin or neuropeptide Y, [1][2] which increases hunger and therefore enhances food consumption.

  4. Orexin receptor - Wikipedia

    en.wikipedia.org/wiki/Orexin_receptor

    However, orexin-B shows a 5- to 10-fold selectivity for orexin receptor type 2, whilst orexin-A is equipotent at both receptors. [2] [3] Several orexin receptor antagonists are in development for potential use in sleep disorders. [4] The first of these, suvorexant, has been on the market in the United States since 2015. [5]

  5. Hunger (physiology) - Wikipedia

    en.wikipedia.org/wiki/Hunger_(physiology)

    Hunger is a sensation that motivates the consumption of food. The sensation of hunger typically manifests after only a few hours without eating and is generally considered to be unpleasant. Satiety occurs between 5 and 20 minutes after eating. [1] There are several theories about how the feeling of hunger arises. [2]

  6. Hypocretin (orexin) receptor 1 - Wikipedia

    en.wikipedia.org/wiki/Hypocretin_(orexin)_receptor_1

    The orexin 1 receptor (OX 1 ), is a G-protein coupled receptor that is heavily expressed in projections from the lateral hypothalamus and is involved in the regulation of feeding behaviour. OX 1 selectively binds the orexin-A neuropeptide. It shares 64% identity with OX 2.

  7. Eating - Wikipedia

    en.wikipedia.org/wiki/Eating

    Eating. Amandines de Provence, poster by Leonetto Cappiello, 1900, which shows a woman eating almond cookies. Eating (also known as consuming) is the ingestion of food. In biology, this is typically done to provide a heterotrophic organism with energy and nutrients and to allow for growth.

  8. Orexin-A - Wikipedia

    en.wikipedia.org/wiki/Orexin-A

    Mechanism. Orexins are highly excitatory neuropeptides that were first discovered in the brains of rats. It is a peptide that is produced by a very small population of cells in the lateral and posterior hypothalamus. Orexins strongly excite various brain nuclei (neurons) to affect an organism's wakefulness by affecting their dopamine ...

  9. Hypocretin (orexin) receptor 2 - Wikipedia

    en.wikipedia.org/wiki/Hypocretin_(orexin)_receptor_2

    structure summary. Orexin receptor type 2 (Ox2R or OX2), also known as hypocretin receptor type 2 (HcrtR2), is a protein that in humans is encoded by the HCRTR2 gene. [5] It should not be confused for the protein CD200R1 which shares the alias OX2R but is a distinct, unrelated gene located on the human chromosome 3.