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[84] [85] [86] The preceding side effects of synthetic estrogens do not appear to occur in pregnant women, who already have very high estrogen levels. [84] This suggests that these effects are due to estrogenic activity. [84] Synthetic estrogens have markedly stronger effects on the liver and hepatic protein synthesis than natural estrogens.
As unopposed estrogen therapy (using estrogen alone without progesterone) increases the risk of endometrial hyperplasia and endometrial cancer in women with intact uteruses, estradiol is usually combined with a progestogen like progesterone or medroxyprogesterone acetate to prevent the effects of estradiol on the endometrium.
The risk of VTE with estradiol/nomegestrol acetate birth control pills is under study. [11] Incidence of irregular vaginal bleeding may be higher with estradiol-containing birth control pills in relation to the fact that estradiol is a weaker estrogen than ethinylestradiol in the endometrium. [3]
"The primary treatment — and the first-line treatment — should be hormone (estrogen) therapy, especially for moderate-to-severe menopause symptoms," Dr. Anna Barbieri, assistant clinical ...
Different sources note different incidence of side effects. The most common side effect is breakthrough bleeding. COC pills can improve conditions such as dysmenorrhea, premenstrual syndrome, and acne, [105] reduce symptoms of endometriosis and polycystic ovary syndrome, and decrease the risk of anemia. [106]
While the role of estrogen, the primary female hormone, in human hair growth isn’t totally clear, it may play a protective role against hair loss in women. Estradiol, a form of estrogen, plays a ...
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