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Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), P-30 antigen, is a glycoprotein enzyme encoded in humans by the KLK3 gene.PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland in men and the paraurethral glands in women.
Exogenous testosterone may cause suppression of spermatogenesis in men, leading to, in some cases, reversible infertility. [76] Gynecomastia and breast tenderness may occur with high dosages of testosterone due to peripheral conversion of testosterone by aromatase into excessive amounts of the estrogen estradiol. [77]
Several things can cause a high PSA, including prostatitis, benign prostate enlargement, or prostate cancer, Dr. Pohlman says. Recent ejaculation can also increase PSA, Dr. Eilber says. PSA ...
Dihydrotestosterone (DHT), a metabolite of testosterone, is a critical mediator of prostatic growth. DHT is synthesized in the prostate from circulating testosterone by the action of the enzyme 5α-reductase, type 2. DHT can act in an autocrine fashion on the stromal cells or in paracrine fashion by diffusing into nearby epithelial cells.
“Elevated PSA levels can be an indicator of prostate issues, including cancer,” Dr. Spratt. Men without prostate cancer typically have PSA levels of under 4 nanograms per milliliter (ng/mL ...
If your PSA is abnormal, your doctor may pause your testosterone therapy until you're evaluated further by a urologist. Myth: Testosterone Causes Baldness It can–but it's complicated.
PAP immunohistochemical staining is often used with PSA (staining), by pathologists, to help distinguish poorly differentiated carcinomas.For example, poorly differentiated prostate adenocarcinoma (prostate cancer) and urothelial carcinoma (bladder cancer) may appear similar under the microscope, but PAP and PSA staining can help differentiate them; [7] prostate adenocarcinoma often stains ...
Injuries to the testicles and cancer treatments like chemotherapy and radiation can cause low testosterone levels. So can some medications (including hormones used to treat prostate cancer), aging ...
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