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Hepatitis B virus (HBV) is a partially double-stranded DNA virus, [1] a species of the genus Orthohepadnavirus and a member of the Hepadnaviridae family of viruses. [ 2 ] [ 3 ] This virus causes the disease hepatitis B .
Hepatitis B infection has been preventable by vaccination since 1982. [4] [12] As of 2022, the hepatitis B vaccine is between 98% and 100% effective in preventing infection. [1] The vaccine is administered in several doses; after an initial dose, two or three more vaccine doses are required at a later time for full effect. [1]
For the medical community, the Hepatitis B Foundation organizes the International HBV Scientific Meeting annually for scientists discuss to new discoveries in hepatitis B research. [12] The organization is also actively involved in policy-making, helping ensure hepatitis B is a health priority at the local and federal level. [13] [14] [15]
The orthohepadnaviruses have been divided into four distinct species, with HBV (human hepatitis B virus), WHV (woodchuck hepatitis virus), GSHV (ground squirrel hepatitis virus ), and WMHBV (woolly monkey hepatitis B virus) as the prototypes, based on the host range from a limited number of studies. From the result of molecular studies about ...
Bersacapavir is an experimental drug for the treatment of hepatitis B. [1] It prevents hepatitis B virus (HBV) from replicating by inhibiting the formation of its capsid. [2] It is also being studied for use in combination with JNJ-73763989, a small interfering RNA that targets HBV RNAs. [3] It can be synthesized beginning with N-methylpyrrole ...
The Asian Liver Center (ALC) was founded in 1996 to spearhead educational outreach and advocacy efforts in the areas of hepatitis B and liver cancer prevention and treatment, serves as a resource for both the general public and health practitioners, and implements clinical and research programs.
Although WMHBV is considerably divergent from the human hepatitis B virus (HBV), they share the same genetic organization. The core gene of WMHBV was the most similar to human HBV with 85.8-86.9% similarity at the amino acid level, while the WHMBV X gene was most divergent from human HBV with only 64.3-65.6% similarity at the amino acid level. [2]
The Hepatitis B virus (HBV) polymerase is a multifunctional enzyme, with both RNA-dependent and DNA-dependent polymerase functions, as well as an RNase H function. It acts on the HBV pre-genomic RNA (pgRNA) to reverse transcribe it to form a new rcDNA molecule within a new capsid.