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Multifocal motor neuropathy (MMN) is a progressively worsening condition where muscles in the extremities gradually weaken. The disorder, a pure motor neuropathy syndrome, is sometimes mistaken for amyotrophic lateral sclerosis (ALS) because of the similarity in the clinical picture, especially if muscle fasciculations are present.
Apart from myelin-directed antibodies, other serum components that can cause demyelination as well as conduction block include complement, cytokines, and other inflammatory mediators. Individuals with chronic inflammatory demyelinating polyneuropathy have a low frequency of specific antibodies, which suggests that different antibodies and ...
Focal demyelination is a hallmark of entrapment neuropathies, which are often characterized by nerve conduction slowing or block. [34] The initial changes are a break-down in the blood nerve barrier, followed by sub-perineurial edema and fibrosis ; localized, then diffuse, demyelination occurs, and finally Wallerian degeneration .
These symptoms are caused specifically by metabolic blocks, demyelination, and axonmetesis. A metabolic block is the temporary deprivation of nourishment from the blood supply which is readily reversed if the ischema does not last too long. [4] Demyelination will interfere with conduction of signals along the nerve. [4]
Electromyographic studies and nerve conduction studies show normal motor conduction velocity and latency with decreased amplitude of compound muscle action potentials. Pathologically, it is a noninflammatory axonopathy without demyelination. [3] Antibodies attack the coating of the motor neurons without causing inflammation or loss of myelin ...
Conduction block means impaired transmission via a part of the nerve. Conduction block can mean myelin damage to the involved area, slowing of conduction or significant spreading out of the temporal profile of the response with axonal integrity is a hallmark of demyelination .
Micrograph showing peripheral neuropathy . Polyneuropathy is peripheral neuropathy occurring in the same areas on both sides of the body. Specialty: Neurology Symptoms: Ataxia [1] Causes: Hereditary (Charcot–Marie–Tooth disease), and acquired (alcohol use disorder) [2] Diagnostic method: Nerve conduction study, urinalysis [3] [1] Treatment
Conduction Block: It occurs when action potentials fail to propagate down the nerve. This is usually due to an extensive loss of myelin that saltatory conduction no longer works, and thus, no signal can be transmitted. A conduction block is apparent on an NCS through a significant drop in amplitude of over 50% “across the area of injury.” [11]
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