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Cell migration is a central process in the development and maintenance of multicellular organisms.Tissue formation during embryonic development, wound healing and immune responses all require the orchestrated movement of cells in particular directions to specific locations.
Collective cell migration describes the movements of group of cells and the emergence of collective behavior from cell-environment interactions and cell-cell communication. Collective cell migration is an essential process in the lives of multicellular organisms , e.g. embryonic development , wound healing and cancer spreading ( metastasis ). [ 1 ]
Primordial germ cells are among the first lineages that are established in development [1] and they are the precursors for gametes. [2] It is thought that the process of primordial germ cell migration itself has been conserved rather than the specific mechanisms within it, as chemoattraction and repulsion seem to have been borrowed from blood cells, neurones, and the mesoderm. [1]
As a result, these changes can cause a cell to rearrange its cytoskeleton in order to facilitate directional migration. [27] [28] A cell's cytoskeleton is a constantly fluctuating network of polymers whose organization greatly depends on the physical environment of the cell. At the focal adhesions, a cell exerts a traction force.
Cell migration plays a huge role in re-epithelialization of the skin and so the study of cell migration can provide advancements in understanding non-healing wounds. [7] Cell migration is also fundamental in developmental processes such as gastrulation and organogenesis. [9] Cell migration is also involved in immune responses and cancer ...
Migration of cells is free toward and away on the axis of the concentration gradient; Detected responses are the results of active migration of cells; Despite the fact that an ideal chemotaxis assay is still not available, there are several protocols and pieces of equipment that offer good correspondence with the conditions described above. The ...
The induced migration of cells from the ganglionic eminence during development is directed by a variety of motogenic factors, molecules that increase cell motility, and chemotactic molecules. The motogenic factor HGF/SF enhances cell motility and directs cells away from subpallial regions and demarcates the routes followed by migrating cells.
There exist two main patterns of cancer cell invasion by cell migration: collective cell migration and individual cell migration, by which tumor cells overcome barriers of the extracellular matrix and spread into surrounding tissues. Each pattern of cell migration exhibits distinct morphological features and is governed by specific biochemical ...