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Pregnenolone (P5), or pregn-5-en-3β-ol-20-one, is an endogenous steroid and precursor/metabolic intermediate in the biosynthesis of most of the steroid hormones, including the progestogens, androgens, estrogens, glucocorticoids, and mineralocorticoids. [1]
The progestogens are named for their function in maintaining pregnancy (i.e., progestational), although they are also present at other phases of the estrous and menstrual cycles. [2] [3] The progestogens are one of three types of sex hormones, the others being estrogens like estradiol and androgens/anabolic steroids like testosterone.
Progesterone ⓘ (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. [1] [13] It belongs to a group of steroid hormones called the progestogens [13] and is the major progestogen in the body.
Pregnenolone, sold under the brand name Enelone among others, is a medication and supplement as well as a naturally occurring and endogenous steroid. [3] [1] [4] [5] [6] It is described as a neurosteroid and anti-inflammatory drug and was used in the treatment of rheumatoid arthritis and soft-tissue rheumatism in the 1950s and is no longer prescribed today, but remains available as a supplement.
Pregnanolone, also known as 3α,5β-tetrahydroprogesterone (3α,5β-THP) or as 5β-pregnan-3α-ol-20-one, is a naturally occurring pregnane steroid and a derivative of progesterone.
1583 13070 Ensembl ENSG00000140459 ENSG00000288362 ENSMUSG00000032323 UniProt P05108 Q9QZ82 RefSeq (mRNA) NM_001099773 NM_000781 NM_019779 NM_001346787 RefSeq (protein) NP_000772 NP_001093243 NP_001333716 NP_062753 Location (UCSC) Chr 15: 74.34 – 74.37 Mb Chr 9: 57.91 – 57.93 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cholesterol side-chain cleavage enzyme is commonly ...
More specifically, the enzyme acts upon pregnenolone and progesterone to add a hydroxyl (-OH) group at carbon 17 position (C17) of the steroid D ring (the 17α-hydroxylase activity, EC 1.14.14.19), or acts upon 17α-hydroxyprogesterone and 17α-hydroxypregnenolone to split the side-chain off the steroid nucleus (the 17,20-lyase activity, EC 1 ...
5α-Dihydroprogesterone (5α-DHP, allopregnanedione, [1] or 5α-pregnane-3,20-dione) is an endogenous progestogen and neurosteroid that is synthesized from progesterone. [2] [3] It is also an intermediate in the synthesis of allopregnanolone and isopregnanolone from progesterone.
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