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Idiopathic granulomatous hepatitis is a rare medical condition characterized by granulomas in the liver, recurrent fever, myalgia, and fatigue. The condition is not a true hepatitis, and some experts believe it is a variant of sarcoidosis. [1] [2]
Granuloma; Picture of a granuloma (without necrosis) as seen through a microscope on a glass slide: The tissue on the slide is stained with two standard dyes (hematoxylin: blue, eosin: pink) to make it visible. The granuloma in this picture was found in a lymph node of a patient with a Mycobacterium avium infection. Specialty: Pathology
It is a form of granuloma. [2] Gummas are most commonly found in the liver (gumma hepatis), but can also be found in brain, heart, skin, bone, testis, and other tissues, leading to a variety of potential problems including neurological disorders or heart valve disease.
While TNF is widely believed to play an important role in the formation of granulomas (this is further supported by the finding that in animal models of mycobacterial granuloma formation inhibition of either TNF or IFN-γ production inhibits granuloma formation), sarcoidosis can and does still develop in those being treated with TNF antagonists ...
The eggs stimulate formation of granuloma around them. The granulomas, consisting of motile cells, carry the eggs to the intestinal lumen. When in the lumen, granuloma cells disperse leaving the eggs to be excreted within feces. Unfortunately, about two-thirds of eggs are not excreted, instead they build up in the gut.
Granulomas try to wall off these organisms and prevent their further growth and spread. Historically widespread and destructive diseases such as tuberculosis, leprosy and syphilis are granulomatous conditions. Granuloma formation is also the feature of many more contemporary conditions, like fungal infections, sarcoidosis and Crohn's disease. [4]
Liver cancer can be primary in which the cancer starts in the liver, or it can be liver metastasis, or secondary, in which the cancer spreads from elsewhere in the body to the liver. Liver metastasis is the more common of the two liver cancers. [3] Instances of liver cancer are increasing globally. [8] [9]
This condition occurs mainly in children and adolescents due to early immune reaction to eggs trapped within the periportal and presinusoidal spaces of the liver creating numerous granulomas. [19] Liver function is not affected, and the severity of liver and spleen enlargement is correlated to the intensity of the infection. [19] It is ...