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6839 20937 Ensembl ENSG00000101945 ENSMUSG00000039231 UniProt O43463 O54864 RefSeq (mRNA) NM_003173 NM_001282166 NM_001290716 NM_011514 NM_001358237 RefSeq (protein) NP_001269095 NP_003164 NP_001277645 NP_035644 NP_001345166 Location (UCSC) Chr X: 48.7 – 48.71 Mb Chr X: 7.93 – 7.94 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Histone-lysine N-methyltransferase SUV39H1 is an ...
General model for duplication of heterochromatin during cell division Microscopy of heterochromatic versus euchromatic nuclei ().. Heterochromatin has been associated with several functions, from gene regulation to the protection of chromosome integrity; [13] some of these roles can be attributed to the dense packing of DNA, which makes it less accessible to protein factors that usually bind ...
The isoforms 1 and 3 of human NPM1 are B23.1 and B23.2 respectively in rat. [7] The isoform 1 is localized to the nucleolus [ 8 ] as is reported for rat B23.1 [ 9 ] [ 10 ] whereas the isoform 3 (B23.2) is nucleoplasmic or cytoplasmic in localization and is expressed at relatively lower levels as compared to isoform 1 in normal rat tissues [ 11 ...
The protoplasmic material of the nucleus including the nucleolus labelled as nucleoplasm. The nucleoplasm, also known as karyoplasm, [1] is the type of protoplasm that makes up the cell nucleus, the most prominent organelle of the eukaryotic cell. It is enclosed by the nuclear envelope, also known as the nuclear membrane. [2]
The nuclear lamina consists of two components, lamins and nuclear lamin-associated membrane proteins. The lamins are type V intermediate filaments which can be categorized as either A-type (lamin A, C) or B-type (lamin B 1, B 2) according to homology of their DNA sequences, biochemical properties and cellular localization during the cell cycle.
Euchromatin (also called "open chromatin") is a lightly packed form of chromatin (DNA, RNA, and protein) that is enriched in genes, and is often (but not always) under active transcription. Euchromatin stands in contrast to heterochromatin , which is tightly packed and less accessible for transcription. 92% of the human genome is euchromatic.
The presence of intra-cellular proteins is common ground, and it is agreed that proteins such as the Scaffold, or Matrix Associated Proteins (SAR or MAR) have some role in the organisation of chromatin in the living cell. There is evidence that the nuclear matrix is involved in regulation of gene expression in Arabidopsis thaliana.
The eukaryotic genome is organized into a compact chromatin structure that allows only regulated access to DNA. The chromatin structure can be globally "open" and more transcriptionally permissive, or globally "condensed" and transcriptionally inactive. The former (euchromatin) is lightly packed and rich in genes under active transcription.