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The entire route, from 1997 and prior, was signed solely as MS 6. In early 1998, US 278 was extended from Tupelo, across northern Mississippi, to Arkansas, with the majority of the route being placed along MS 6. US 278 went unsigned for many years, well into the 2000s, and when it finally was signed, MS 6 signs were never removed.
Major junctions of U.S. 45 in Mississippi include U.S. Route 84 at Waynesboro, Interstate 20/59 at Meridian, U.S. Route 82 at Columbus, Interstate 22/U.S. Route 78 at Tupelo and U.S. Route 72 at Corinth. Each of these junctions is an interchange and, with the exception of Columbus and Waynesboro, each is part of a freeway segment.
U.S. Route 72 (US 72) is an east–west United States highway that travels for 317.811 miles (511.467 km) from southwestern Tennessee, throughout North Mississippi, North Alabama, and southeastern Tennessee.
Interstate 22 (I-22) is a 202.22-mile-long (325.44 km) Interstate Highway in the US states of Mississippi and Alabama, connecting I-269 near Byhalia, Mississippi, to I-65 near Birmingham, Alabama.
MS 145 in Tupelo: MS 145 in Tupelo — — Unsigned, fully locally maintained MS 770: 0.221: 0.356 MS 9 / MS 338 in Pontotoc: MS 15 in Pontotoc — — Unsigned MS 772: 1.094: 1.761 CR 123 in Algoma: MS 15 / CR 124 in Algoma — — MS 773: 1.915: 3.082 MS 2 near Ripley: CR 500 / CR 549 near Ripley 2004: current MS 774: 0.208: 0.335 MS 145 in ...
U.S. Route 78 (US 78) is an east–west United States Numbered Highway that runs for 843.6 miles (1,357.6 km) from Swifton, Arkansas, to Charleston, South Carolina.From Byhalia, Mississippi to Graysville, Alabama, US 78 runs concurrently with Interstate 22 (I-22).
U.S. Route 45 Alternate (US 45 Alternate, also signed as US 45A) is a 62.9-mile-long (101.2 km) alternate route of US 45 in northeastern Mississippi, running from Brooksville, through West Point, to Shannon, which lies just south of Tupelo.
The 1933 Road Map of Mississippi shows MS 25 running northward from Macon roughly along the 2019 alignment of U.S. Route 45 to Brooksville, then roughly along the 2019 alignment of U.S. Route 45 Alternate through Artesia and West Point to Muldon, where the 2019 alignment continues in a northeasterly direction.